Divergent synthesis of D-erythro-sphingosine, L-threo-sphingosine, and their regioisomers

• Starting from a vinyl epoxide, a divergent synthesis of four sphingosine isomers is described. The remaining four isomers can easily be synthesized using the same methodology. Although numerous syntheses of sphingosine have been published, this is the first general route leading to all eight isomers in this important compound class. The synthetic strategy relies on regioselective opening of a vinyl epoxide and a vinylaziridine in the allylic position.

Subject headings

NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

Keyword

beta-amino alcohols

stereoselective synthesis

enantioselective synthesis

l-serine

route

regiodivergent

derivatives

products

organisk kemi

Publication and Content Type

ref (subject category)

art (subject category)