How many human proteoforms are there?

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Kelleher Neil L.) > How many human prot...

1 of 6
Previous record
Next record
To hitlist

Details
MARC

Aebersold, Ruedi (author)

How many human proteoforms are there?

Article/chapterEnglish2018

Publisher, publication year, extent ...

NATURE PUBLISHING GROUP,2018
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:kth-223782
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-223782URI
https://doi.org/10.1038/NCHEMBIO.2576DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

QC 2018307
Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA-and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype.

Subject headings and genre

NATURVETENSKAP Biologi hsv//swe
NATURAL SCIENCES Biological Sciences hsv//eng

Added entries (persons, corporate bodies, meetings, titles ...)

Agar, Jeffrey N. (author)
Amster, I. Jonathan (author)
Baker, Mark S. (author)
Bertozzi, Carolyn R. (author)
Boja, Emily S. (author)
Costello, Catherine E. (author)
Cravatt, Benjamin F. (author)
Fenselau, Catherine (author)
Garcia, Benjamin A. (author)
Ge, Ying (author)
Gunawardena, Jeremy (author)
Hendrickson, Ronald C. (author)
Hergenrother, Paul J. (author)
Huber, Christian G. (author)
Ivanov, Alexander R. (author)
Jensen, Ole N. (author)
Jewett, Michael C. (author)
Kelleher, Neil L. (author)
Kiessling, Laura L. (author)
Krogan, Nevan J. (author)
Larsen, Martin R. (author)
Loo, Joseph A. (author)
Loo, Rachel R. Ogorzalek (author)
Lundberg, EmmaKTH,Science for Life Laboratory, SciLifeLab,Stanford Univ, Dept Genet, Stanford, CA 94305 USA(Swepub:kth)u12bylj1 (author)
MacCoss, Michael J. (author)
Mallick, Parag (author)
Mootha, Vamsi K. (author)
Mrksich, Milan (author)
Muir, Tom W. (author)
Patrie, Steven M. (author)
Pesavento, James J. (author)
Pitteri, Sharon J. (author)
Rodriguez, Henry (author)
Saghatelian, Alan (author)
Sandoval, Wendy (author)
Schluter, Hartmut (author)
Sechi, Salvatore (author)
Slavoff, Sarah A. (author)
Smith, Lloyd M. (author)
Snyder, Michael P. (author)
Thomas, Paul M. (author)
Uhlen, Mathias (author)
Van Eyk, Jennifer E. (author)
Vidal, Marc (author)
Walt, David R. (author)
White, Forest M. (author)
Williams, Evan R. (author)
Wohlschlager, Therese (author)
Wysocki, Vicki H. (author)
Yates, Nathan A. (author)
Young, Nicolas L. (author)
Zhang, Bing (author)
KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

In:Nature Chemical Biology: NATURE PUBLISHING GROUP14:3, s. 206-2141552-44501552-4469

Internet link

Find in a library

Nature Chemical Biology (Search for host publication in LIBRIS)

To the university's database

1 of 6
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Aebersold, Ruedi; Agar, Jeffrey N.; Amster, I. Jonat ...; Baker, Mark S.; Bertozzi, Caroly ...; Boja, Emily S.; show more...; Costello, Cather ...; Cravatt, Benjami ...; Fenselau, Cather ...; Garcia, Benjamin ...; Ge, Ying; Gunawardena, Jer ...; Hendrickson, Ron ...; Hergenrother, Pa ...; Huber, Christian ...; Ivanov, Alexande ...; Jensen, Ole N.; Jewett, Michael ...; Kelleher, Neil L ...; Kiessling, Laura ...; Krogan, Nevan J.; Larsen, Martin R ...; Loo, Joseph A.; Loo, Rachel R. O ...; Lundberg, Emma; MacCoss, Michael ...; Mallick, Parag; Mootha, Vamsi K.; Mrksich, Milan; Muir, Tom W.; Patrie, Steven M ...; Pesavento, James ...; Pitteri, Sharon ...; Rodriguez, Henry; Saghatelian, Ala ...; Sandoval, Wendy; Schluter, Hartmu ...; Sechi, Salvatore; Slavoff, Sarah A ...; Smith, Lloyd M.; Snyder, Michael ...; Thomas, Paul M.; Uhlen, Mathias; Van Eyk, Jennife ...; Vidal, Marc; Walt, David R.; White, Forest M.; Williams, Evan R ...; Wohlschlager, Th ...; Wysocki, Vicki H ...; Yates, Nathan A.; Young, Nicolas L ...; Zhang, Bing; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...

Articles in the publication: Nature Chemical ...

By the university: Royal Institute of Technology

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se