Experimental study for agglomeration behaviour of paracetamol in acetone-toluene-water systems

• Agglomeration behaviour of paracetamol was studied in acetone-toluene-water systems. The aim was to experimentally determine how the solvent composition influences the agglomeration tendency of paracetamol. It was found that for the chosen solvent system there is one main region where paracetamol agglomerates: the region with large amounts of acetone (>65 wt%) and very small amounts of water (<4 wt%). The same behaviour can be observed both within the one-phase region and within the two-phase region. The experimental agglomeration results were compared with molecular simulations from literature. Both methods indicate that it is more likely for paracetamol crystals to agglomerate in organic systems than in aqueous systems.

Nyckelord

paracetamol

agglomeration

solvent composition

binary solvent mixtures

acetaminophen

growth

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