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  • Carreras-Puigvert, JordiKarolinska Institutet,Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)

A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-11-16
  • Nature Publishing Group,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-227131
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227131URI
  • https://doi.org/10.1038/s41467-017-01642-wDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-149800URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137042071URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333888URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20180503
  • The NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing. Although highly conserved throughout all organisms, their biological roles and biochemical redundancies remain largely unclear. To address this, we globally resolve their individual properties and inter-relationships. We purify 18 of the human NUDIX proteins and screen 52 substrates, providing a substrate redundancy map. Using crystal structures, we generate sequence alignment analyses revealing four major structural classes. To a certain extent, their substrate preference redundancies correlate with structural classes, thus linking structure and activity relationships. To elucidate interdependence among the NUDIX hydrolases, we pairwise deplete them generating an epistatic interaction map, evaluate cell cycle perturbations upon knockdown in normal and cancer cells, and analyse their protein and mRNA expression in normal and cancer tissues. Using a novel FUSION algorithm, we integrate all data creating a comprehensive NUDIX enzyme profile map, which will prove fundamental to understanding their biological functionality.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Zitnik, M.Univ Ljubljana, Fac Comp & Informat Sci, SI-1000 Ljubljana, Slovenia.; Stanford Univ, Dept Comp Sci, Palo Alto, CA 94305 USA (author)
  • Jemth, A. -SKarolinska Institutet,Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Carter, MeganStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden(Swepub:su)mbult (author)
  • Unterlass, J. E.Karolinska Institutet,Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Hallström, Björn M.KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Cell Profiling Affin Prote, S-17165 Stockholm, Sweden(Swepub:kth)u1ih19oh (author)
  • Loseva, O.Karolinska Institutet,Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Karem, Z.Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Calderón-Montanõ, J. M.Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Lindskog, CeciliaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)cecli129 (author)
  • Edqvist, Per-Henrik DUppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi(Swepub:uu)peedq227 (author)
  • Matuszewski, Damian J.Uppsala universitet,Avdelningen för visuell information och interaktion,Science for Life Laboratory, SciLifeLab(Swepub:uu)damma800 (author)
  • Ait Blal, HammouKTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Cell Profiling Affin Prote, S-17165 Stockholm, Sweden(Swepub:kth)u1rkiscj (author)
  • Berntsson, Ronnie P. A.Stockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden(Swepub:su)rbern (author)
  • Häggblad, MariaStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Biochem & Cellular Screening Facil, S-17165 Stockholm, Sweden(Swepub:su)maha7002 (author)
  • Martens, UlfStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Biochem & Cellular Screening Facil, S-17165 Stockholm, Sweden(Swepub:su)ulma3535 (author)
  • Studham, M.Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Stockholm Bioinformat Ctr, Sci Life Lab, Box 1031, S-17121 Solna, Sweden (author)
  • Lundgren, BoStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Biochem & Cellular Screening Facil, S-17165 Stockholm, Sweden(Swepub:su)bolu7255 (author)
  • Wählby, Carolina,1974-Uppsala universitet,Avdelningen för visuell information och interaktion,Science for Life Laboratory, SciLifeLab,Bildanalys och människa-datorinteraktion(Swepub:uu)cli05194 (author)
  • Sonnhammer, Erik L. L.Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Dept Biochem & Biophys, Stockholm Bioinformat Ctr, Sci Life Lab, Box 1031, S-17121 Solna, Sweden(Swepub:su)esonn (author)
  • Lundberg, EmmaKTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Cell Profiling Affin Prote, S-17165 Stockholm, Sweden(Swepub:kth)u12bylj1 (author)
  • Stenmark, PålStockholms universitet,Institutionen för biokemi och biofysik,Stockholm Univ, Dept Biochem & Biophys, S-10691 Stockholm, Sweden(Swepub:su)stenm (author)
  • Zupan, B.Univ Ljubljana, Fac Comp & Informat Sci, SI-1000 Ljubljana, Slovenia.; Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA (author)
  • Helleday, T.Karolinska Institutet,Karolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (author)
  • Karolinska InstitutetKarolinska Inst, Div Translat Med & Chem Biol, Dept Mol Biochem & Biophys, Sci Life Lab, S-17165 Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Nature Communications: Nature Publishing Group8:12041-1723

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