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Sökning: WFRF:(Lakshmikanth Tadepally) > Immune system adapt...

Immune system adaptation during gender-affirming testosterone treatment

Lakshmikanth, Tadepally (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Consiglio, Camila (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden; Department of Laboratory Medicine, Lund University, Lund, Sweden
Sardh, Fabian (författare)
Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
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Forlin, Rikard (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Wang, Jun (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Tan, Ziyang (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Barcenilla, Hugo (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Rodriguez, Lucie (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Sugrue, Jamie (författare)
Translational Immunology Unit, Institut Pasteur, Paris, France
Noori, Peri (författare)
Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden
Ivanchenko, Margarita (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Piñero Páez, Laura (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Gonzalez, Laura (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Habimana Mugabo, Constantin (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Johnsson, Anette (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Ryberg, Henrik (författare)
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Gothenburg, Sweden
Hallgren, Åsa (författare)
Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden
Pou, Christian (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Chen, Yang (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Mikeš, Jaromír (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
James, Anna (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden
Dahlqvist, Per (författare)
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
Wahlberg, Jeanette, 1969- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Hagelin, Anders (författare)
ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Holmberg, Mats (författare)
ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Degerblad, Marie (författare)
ANOVA, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden
Isaksson, Magnus (författare)
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Duffy, Darragh (författare)
Translational Immunology Unit, Institut Pasteur, Paris, France
Kämpe, Olle (författare)
Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden
Landegren, Nils (författare)
Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Solna, Sweden; Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
Brodin, Petter (författare)
Department of Women's and Children's Health, Karolinska Institutet, Solna, Sweden; Medical Research Council, Laboratory of Medical Sciences, London, UK; Department of Immunology and Inflammation, Imperial College London, London, UK
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 (creator_code:org_t)
Nature Publishing Group, 2024
2024
Engelska.
Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 633:8028, s. 155-164
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Infectious, inflammatory and autoimmune conditions present differently in males and females. SARS-CoV-2 infection in naive males is associated with increased risk of death, whereas females are at increased risk of long COVID, similar to observations in other infections. Females respond more strongly to vaccines, and adverse reactions are more frequent, like most autoimmune diseases. Immunological sex differences stem from genetic, hormonal and behavioural factors but their relative importance is only partially understood. In individuals assigned female sex at birth and undergoing gender-affirming testosterone therapy (trans men), hormone concentrations change markedly but the immunological consequences are poorly understood. Here we performed longitudinal systems-level analyses in 23 trans men and found that testosterone modulates a cross-regulated axis between type-I interferon and tumour necrosis factor. This is mediated by functional attenuation of type-I interferon responses in both plasmacytoid dendritic cells and monocytes. Conversely, testosterone potentiates monocyte responses leading to increased tumour necrosis factor, interleukin-6 and interleukin-15 production and downstream activation of nuclear factor kappa B-regulated genes and potentiation of interferon-γ responses, primarily in natural killer cells. These findings in trans men are corroborated by sex-divergent responses in public datasets and illustrate the dynamic regulation of human immunity by sex hormones, with implications for the health of individuals undergoing hormone therapy and our understanding of sex-divergent immune responses in cisgender individuals.

Ämnesord

NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

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