Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

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Ritsinger, V.Karolinska Institutet (author)

Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction : A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

Article/chapterEnglish2018

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2018-07-11
SAGE Publications Ltd,2018
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LIBRIS-ID:oai:DiVA.org:kth-236723
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-236723URI
https://doi.org/10.1177/1479164118781892DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152219URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:139107841URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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QC 20181023
Objective: To investigate the long-term prognostic value of insulin-like growth factor-binding protein 1 in patients with acute myocardial infarction. Methods: Patients (n = 180) with admission glucose < 11 mmol/L without previously known diabetes admitted for an acute myocardial infarction in 1998–2000 were followed for mortality and cardiovascular events (first of cardiovascular mortality/acute myocardial infarction/stroke/severe heart failure) until the end of 2011 (median 11.6 years). Fasting levels of insulin-like growth factor-binding protein 1 at day 2 were related to outcome in Cox proportional hazard regression analyses. Results: Median age was 64 years, 69% were male and median insulin-like growth factor-binding protein 1 was 20 µg/L. Total mortality was 34% (n = 61) and 44% (n = 80) experienced a cardiovascular event during a median follow-up time of 11.6 years. After age adjustment, insulin-like growth factor-binding protein 1 was associated with all-cause (1.40; 1.02–1.93, p = 0.039) and cancer mortality (2.09; 1.15–3.79, p = 0.015) but not with cardiovascular death (p = 0.29) or cardiovascular events (p = 0.57). After adjustments also for previous myocardial infarction, previous heart failure and body mass index, insulin-like growth factor-binding protein 1 was still associated with all-cause mortality (1.38; 1.01–1.89, p = 0.046). Conclusion: In patients with acute myocardial infarction without previously known diabetes, high insulin-like growth factor-binding protein 1 was associated with long-term all-cause and cancer mortality but not with cardiovascular events.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
abnormal glucose tolerance
Acute myocardial infarction
insulin-like growth factor-binding protein 1
prognosis
glucose
hemoglobin A1c
insulin
lipid
proinsulin
somatomedin binding protein 1
somatomedin C
biological marker
IGFBP1 protein
human
acute heart infarction
adult
aged
all cause mortality
Article
body mass
cancer mortality
cardiovascular mortality
cerebrovascular accident
cohort analysis
controlled study
disease severity
fasting
female
follow up
glucose blood level
glucose tolerance
heart failure
hospital admission
human
insulin blood level
lipid blood level
long term care
major clinical study
male
outcome assessment
protein blood level
blood
cause of death
chi square distribution
disease exacerbation
heart infarction
Kaplan Meier method
metabolism
middle aged
mortality
neoplasm
proportional hazards model
risk factor
time factor
upregulation
Biomarkers
Blood Glucose
Chi-Square Distribution
Disease Progression
Follow-Up Studies
Humans
Insulin-Like Growth Factor Binding Protein 1
Kaplan-Meier Estimate
Myocardial Infarction
Neoplasms
Proportional Hazards Models
Risk Factors
Time Factors
Up-Regulation

Added entries (persons, corporate bodies, meetings, titles ...)

Brismar, K.Karolinska Institutet (author)
Mellbin, L.Karolinska Institutet (author)
Näsman, PerKTH,Fastighetsekonomi och finans(Swepub:kth)u1ghoqwp (author)
Rydén, L.Karolinska Institutet (author)
Söderberg, StefanUmeå universitet,Kardiologi(Swepub:umu)stso0001 (author)
Norhammar, A.Karolinska Institutet (author)
Karolinska InstitutetFastighetsekonomi och finans (creator_code:org_t)

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In:Diabetes & Vascular Disease Research: SAGE Publications Ltd15:5, s. 387-3951479-16411752-8984

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