Search: WFRF:(Paulsson Berne G.)
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Novel Multiomics Pr...
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
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- Matic, L. P. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Iglesias, Maria Jesus (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Vesterlund, M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Canc Prote, Stockholm, Sweden.
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- Lengquist, M. (author)
- Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Hong, Mun-Gwan (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Saieed, S. (author)
- Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Sanchez-Rivera, Laura (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Berg, M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Razuvaev, A. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Kronqvist, M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Lund, K. (author)
- Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Caidahl, K. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Gillgren, P. (author)
- Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Dept Surg, Stockholm, Sweden.
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- Pontén, Fredrik (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Klinisk och experimentell patologi
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Hansson, G. K. (author)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Paulsson-Berne, G. (author)
- Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Fagman, Erika (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology
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- Roy, J. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Hultgren, R. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Lehtiö, J. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Canc Prote, Stockholm, Sweden.
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- Odeberg, Jacob (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Ctr Hematol, Coagulat Unit, Stockholm, Sweden.
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- Hedin, U. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: JACC: Basic to Translational Science. - : Elsevier BV. - 2452-302X. ; 3:4, s. 464-480
- Related links:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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Abstract
Subject headings
Close
- Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- atherosclerosis
- biomarkers
- intraplaque hemorrhage
- omics analyses
- translational studies
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Matic, L. P.
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Iglesias, Maria ...
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Vesterlund, M.
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Lengquist, M.
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Hong, Mun-Gwan
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Saieed, S.
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show more...
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Sanchez-Rivera, ...
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Berg, M.
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Razuvaev, A.
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Kronqvist, M.
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Lund, K.
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Caidahl, K.
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Gillgren, P.
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Pontén, Fredrik
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Uhlén, Mathias
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Schwenk, Jochen ...
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Hansson, G. K.
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Paulsson-Berne, ...
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Fagman, Erika
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Roy, J.
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Hultgren, R.
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Bergström, Göran ...
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Lehtiö, J.
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Odeberg, Jacob
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Hedin, U.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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JACC: Basic to T ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University
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University of Gothenburg