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  • Gunasekera, Sunithi,1977-Uppsala universitet,Farmakognosi (author)

Stabilized Cyclic Peptides as Scavengers of Autoantibodies : Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-04-09
  • American Chemical Society (ACS),2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-238191
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-238191URI
  • https://doi.org/10.1021/acschembio.8b00118DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358527URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138543614URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20181120
  • The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope α-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Fernandes-Cerqueira, C.Karolinska Institutet (author)
  • Wennmalm, Stefan,1970-KTH,Experimentell biomolekylär fysik,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Scilifelab, Appl Phys, Expt Biomol Phys, Tomtebodavagen 23, S-17165 Stockholm, Sweden(Swepub:kth)u1wq1pdv (author)
  • Wähämaa, H.Karolinska Institutet (author)
  • Sommarin, Y.Eurodiagnost AB, S-21224 Malmo, Sweden (author)
  • Catrina, A. I.Karolinska Institutet (author)
  • Jakobsson, P. -JKarolinska Institutet (author)
  • Göransson, Ulf,1970-Uppsala universitet,Farmakognosi(Swepub:uu)ugo29049 (author)
  • Uppsala universitetFarmakognosi (creator_code:org_t)

Related titles

  • In:ACS Chemical Biology: American Chemical Society (ACS)13:6, s. 1525-15351554-89291554-8937

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