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The inverse associa...
The inverse association between a fish consumption biomarker with gingival inflammation and periodontitis : a population-based study
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- Ottosson, Filip (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
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- Hultgren, Lina (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Public Dental Service of Skåne, Lund, Sweden
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- Fernandez, Celine (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Engström, Gunnar (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden
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- Orho-Melander, Marju (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
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- Kennbäck, Cecilia (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden
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- Persson, Margaretha (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden
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- Demmer, Ryan T (författare)
- School of Public Health, University of Minnesota, Minneapolis, MN, USA; Mailman School of Public Health, Columbia University, NY, USA
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- Melander, Olle (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden
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- Klinge, Björn (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Department of Dental Medicine, Karolinska Institutet, Solna, Sweden
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- Nilsson, Peter (författare)
- Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden
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- Jönsson, Daniel (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden; Public Dental Service of Skåne, Lund, Sweden
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(creator_code:org_t)
- 2022-02-27
- 2022
- Engelska.
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Ingår i: Journal of Clinical Periodontology. - : John Wiley & Sons. - 0303-6979 .- 1600-051X. ; 49:4, s. 353-361
- Relaterad länk:
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https://doi.org/10.1...
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- AIM: The metabolite 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is a fatty fish-intake biomarker. We investigated the association between plasma levels of CMPF in relation to gingival inflammation and periodontitis case definition, as well as extent and severity variables.METHODS: The Malmö Offspring Study (MOS) is a population-based study, and the Malmö Offspring Dental Study (MODS) is its dental arm, including periodontal charting. Plasma CMPF was measured using liquid chromatography-mass spectrometry and studied in relation to periodontal diagnosis and parameters using multivariable linear or logistic regression modelling adjusting for age, sex, education, BMI, fasting glucose and smoking.RESULTS: Metabolite data were available for 922 MODS participants. Higher CMPF levels were associated with less gingival inflammation (beta -2.12, p=0.002), and lower odds of severe periodontitis (OR 0.74, 95% CI=0.56-0.98). Higher CMPF levels were also associated with more teeth (beta 0.19, p=0.001), lower number of periodontal pockets (>4 mm) (beta -1.07, p=0.007) and lower odds of having two or more >6 mm periodontal pockets (OR 0.80, 95% CI=0.65-0.98) in fully adjusted models.CONCLUSION: CMPF, a validated biomarker of fatty fish consumption, is associated with less periodontal inflammation and periodontitis. Residual confounding cannot be ruled out and future studies are warranted. This article is protected by copyright. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- CMPF
- fish diet
- gingival inflammation
- metabolomics
- periodontitis
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- ref (ämneskategori)
- art (ämneskategori)
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Ottosson, Filip
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Hultgren, Lina
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Fernandez, Celin ...
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Engström, Gunnar
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Orho-Melander, M ...
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Kennbäck, Cecili ...
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Persson, Margare ...
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Demmer, Ryan T
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Melander, Olle
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Klinge, Björn
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Nilsson, Peter
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Jönsson, Daniel
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Malmö universitet