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Spatiotemporal dyna...
Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis
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- Maniatis, Silas (author)
- New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.
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- Aijo, Tarmo (author)
- Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA.
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- Vickovic, Sanja (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Braine, Catherine (author)
- New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.;Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA.
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- Kang, Kristy (author)
- New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.
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- Mollbrink, Annelie (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Fagegaltier, Delphine (author)
- New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.
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- Andrusivova, Zaneta (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Saarenpaa, Sami (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Saiz-Castro, Gonzalo (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Cuevas, Miguel (author)
- Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA.
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- Watters, Aaron (author)
- Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA.
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Bonneau, Richard (author)
- Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA.;NYU, Ctr Data Sci, New York, NY 10011 USA.
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- Phatnani, Hemali (author)
- New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA.;Columbia Univ, Mortimer B Zuckerman Mind Brain Behav Inst, New York, NY 10032 USA.
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New York Genome Ctr, Ctr Genom Neurodegenerat Dis, New York, NY 10013 USA Flatiron Inst, Ctr Computat Biol, New York, NY 10010 USA. (creator_code:org_t)
- AMER ASSOC ADVANCEMENT SCIENCE, 2019
- 2019
- English.
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In: Science. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075 .- 1095-9203. ; 364:6435, s. 89-
- Related links:
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https://www.biorxiv....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Paralysis occurring in amyotrophic lateral sclerosis (ALS) results from denervation of skeletal muscle as a consequence of motor neuron degeneration. Interactions between motor neurons and glia contribute to motor neuron loss, but the spatiotemporal ordering of molecular events that drive these processes in intact spinal tissue remains poorly understood. Here, we use spatial transcriptomics to obtain gene expression measurements of mouse spinal cords over the course of disease, as well as of postmortem tissue from ALS patients, to characterize the underlying molecular mechanisms in ALS. We identify pathway dynamics, distinguish regional differences between microglia and astrocyte populations at early time points, and discern perturbations in several transcriptional pathways shared between murine models of ALS and human postmortem spinal cords.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Science
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- By the author/editor
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Maniatis, Silas
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Aijo, Tarmo
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Vickovic, Sanja
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Braine, Catherin ...
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Kang, Kristy
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Mollbrink, Annel ...
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show more...
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Fagegaltier, Del ...
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Andrusivova, Zan ...
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Saarenpaa, Sami
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Saiz-Castro, Gon ...
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Cuevas, Miguel
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Watters, Aaron
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Lundeberg, Joaki ...
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Bonneau, Richard
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Phatnani, Hemali
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Science
- By the university
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Royal Institute of Technology