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Hypoxia-enhanced Bl...
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
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- Park, Tae-Eun (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.;UNIST, UNIST Gil 50, Ulsan 44919, South Korea.
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- Mustafaoglu, Nur (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Herland, Anna (författare)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik,Harvard Univ, USA ;Karolinska Inst, Swedish Med Nanosci Ctr, Dept Neurosci, Stockholm, Sweden.
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- Hasselkus, Ryan (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Mannix, Robert (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA.;Boston Childrens Hosp, Dept Surg, Boston, MA 02115 USA.
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- FitzGerald, Edward A. (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Prantil-Baun, Rachelle (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Watters, Alexander (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Henry, Olivier (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Benz, Maximilian (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- Sanchez, Henry (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
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- McCrea, Heather J. (författare)
- Boston Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Goumnerova, Liliana Christova (författare)
- Boston Childrens Hosp, Dept Neurosurg, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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- Song, Hannah W. (författare)
- Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA.
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- Palecek, Sean P. (författare)
- Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA.
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- Shusta, Eric (författare)
- Univ Wisconsin, Dept Chem & Biol Engn, Madison, WI 53706 USA.
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- Ingber, Donald E. (författare)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.;Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA.;Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA.;Boston Childrens Hosp, Dept Surg, Boston, MA 02115 USA.
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Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;UNIST, UNIST Gil 50, Ulsan 44919, South Korea. Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA. (creator_code:org_t)
- 2019-06-13
- 2019
- Engelska.
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Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced pluripotent stem cell-derived human brain microvascular endothelium interfaced with primary human brain astrocytes and pericytes that recapitulates the high level of barrier function of the in vivo human BBB for at least one week in culture. The endothelium expresses high levels of tight junction proteins and functional efflux pumps, and it displays selective transcytosis of peptides and antibodies previously observed in vivo. Increased barrier functionality was accomplished using a developmentally-inspired induction protocol that includes a period of differentiation under hypoxic conditions. This enhanced BBB Chip may therefore represent a new in vitro tool for development and validation of delivery systems that transport drugs and therapeutic antibodies across the human BBB.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
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Park, Tae-Eun
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Mustafaoglu, Nur
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Herland, Anna
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Hasselkus, Ryan
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Mannix, Robert
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FitzGerald, Edwa ...
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visa fler...
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Prantil-Baun, Ra ...
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Watters, Alexand ...
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Henry, Olivier
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Benz, Maximilian
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Sanchez, Henry
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McCrea, Heather ...
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Goumnerova, Lili ...
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Song, Hannah W.
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Palecek, Sean P.
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Shusta, Eric
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Ingber, Donald E ...
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- Om ämnet
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- TEKNIK OCH TEKNOLOGIER
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TEKNIK OCH TEKNO ...
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och Nanoteknik
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Nature Communica ...
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Kungliga Tekniska Högskolan
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Karolinska Institutet