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Capillary-Fiber Bas...
Capillary-Fiber Based Electrophoretic Delivery Device
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- Poxson, David (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Gabrielsson, Erik (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Bonisoli, Alberto (författare)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten,Ist Italiano Tecnol, Italy; St Anna Sch Adv Studies, Italy
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- Linderhed, Ulrika (författare)
- Linköpings universitet,RISE,Acreo,Linköping University, Sweden,Laboratoriet för organisk elektronik,Tekniska fakulteten,Res Inst Sweden, Sweden
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- Abrahamsson, Tobias (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Matthiesen, Isabelle (författare)
- Linköpings universitet,KTH,Mikro- och nanosystemteknik,Linköping University, Sweden; KTH Royal Institute of Technology, Sweden,Laboratoriet för organisk elektronik,Tekniska fakulteten,KTH Royal Inst Technol, Sweden
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- Tybrandt, Klas (författare)
- Linköpings universitet,Fysik och elektroteknik,Tekniska fakulteten
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- Berggren, Magnus (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Simon, Daniel (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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(creator_code:org_t)
- 2019-03-27
- 2019
- Engelska.
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Ingår i: ACS Applied Materials and Interfaces. - : American Chemical Society. - 1944-8244 .- 1944-8252. ; 11:15, s. 14200-14207
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Organic electronic ion pumps (OEIPs) are versatile tools for electrophoretic delivery of substances with high spatiotemporal resolution. To date, OEIPs and similar iontronic components have been fabricated using thin-film techniques and often rely on laborious, multistep photolithographic processes. OEIPs have been demonstrated in a variety of in vitro and in vivo settings for controlling biological systems, but the thin-film form factor and limited repertoire of polyelectrolyte materials and device fabrication techniques unnecessarily constrain the possibilities for miniaturization and extremely localized substance delivery, e.g., the greater range of pharmaceutical compounds, on the scale of a single cell. Here, we demonstrate an entirely new OEIP form factor based on capillary fibers that include hyperbranched polyglycerols (dPGs) as the selective electrophoretic membrane. The dPGs enable electrophoretic channels with a high concentration of fixed charges and well-controlled cross-linking and can be realized using a simple "one-pot" fluidic manufacturing protocol. Selective electrophoretic transport of cations and anions of various sizes is demonstrated, including "large" substances that are difficult to transport with other OEIP technologies. We present a method for tailoring and characterizing the electrophoretic channels' fixed charge concentration in the operational state. Subsequently, we compare the experimental performance of these capillary OEIPs to a computational model and explain unexpected features in the ionic current for the transport and delivery of larger, lower-mobility ionic compounds. From this model, we are able to elucidate several operational and design principles relevant to miniaturized electrophoretic drug delivery technologies in general. Overall, the compactness of the capillary OEIP enables electrophoretic delivery devices with probelike geometries, suitable for a variety of ionic compounds, paving the way for less-invasive implantation into biological systems and for healthcare applications.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Annan teknik -- Övrig annan teknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies -- Other Engineering and Technologies not elsewhere specified (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- bioelectronics
- electrophoresis
- hyperbranched polymer
- iontronics
- polyelectrolyte
- substance delivery
- Approximation theory
- Biological materials
- Biological systems
- Dendrimers
- Electric charge
- Photolithography
- Polyelectrolytes
- Targeted drug delivery
- Thin films
- Drug delivery technologies
- Hyperbranched polyglycerols
- Hyperbranched polymers
- Photolithographic process
- Spatio-temporal resolution
- Controlled drug delivery
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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