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High-definition spa...
High-definition spatial transcriptomics for in situ tissue profiling
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- Vickovic, Sanja (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
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- Eraslan, Gokcen (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
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- Salmén, Fredrik (author)
- KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Klughammer, Johanna (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
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- Stenbeck, Linnea (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Schapiro, Denis (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA.,Broad Institute,Harvard University
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- Aijo, Tarmo (author)
- Flatiron Inst, Ctr Computat Biol, New York, NY USA.,Flatiron Institute
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- Bonneau, Richard (author)
- NYU, Ctr Data Sci, New York, NY USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,New York University
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- Bergenstrahle, Joseph (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Fernandez Navarro, Jose (author)
- KTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Gould, Joshua (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
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- Griffin, Gabriel K. (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,Broad Institute
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- Borg, Åke (author)
- Lund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Familial Breast Cancer,Lund University Research Groups
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- Ronaghi, Mostafa (author)
- Illumina Inc, San Diego, CA USA.
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- Frisen, Jonas (author)
- Karolinska Institutet,Karolinska Institute
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- Lundeberg, Joakim (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.,Stanford University
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- Regev, Aviv (author)
- Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;MIT, Howard Hughes Med Inst, Cambridge, MA USA.;MIT, Dept Biol, Koch Inst Integrat Canc Res, Cambridge, MA USA.,Broad Institute,Massachusetts Institute of Technology
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- Ståhl, Patrik, Dr. (author)
- KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Bergenstråhle, Ludvig (author)
- KTH Royal Institute of Technology
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(creator_code:org_t)
- 2019-09-09
- 2019
- English.
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In: Nature Methods. - : NATURE PUBLISHING GROUP. - 1548-7091 .- 1548-7105. ; 16:10, s. 987-
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Abstract
Subject headings
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- Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcriptcoupled spatial barcodes at 2-mu m resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Vickovic, Sanja
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Eraslan, Gokcen
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Salmén, Fredrik
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Klughammer, Joha ...
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Stenbeck, Linnea
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Schapiro, Denis
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show more...
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Aijo, Tarmo
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Bonneau, Richard
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Bergenstrahle, J ...
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Fernandez Navarr ...
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Gould, Joshua
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Griffin, Gabriel ...
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Borg, Åke
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Ronaghi, Mostafa
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Frisen, Jonas
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Lundeberg, Joaki ...
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Regev, Aviv
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Ståhl, Patrik, D ...
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Bergenstråhle, L ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Laborato ...
- Articles in the publication
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Nature Methods
- By the university
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Royal Institute of Technology
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Lund University
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Karolinska Institutet