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Comprehensive inves...
Comprehensive investigation of key biomarkers and pathways in hepatitis B virus-related hepatocellular carcinoma
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- Liao, Xiwen (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Yu, Tingdong (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Yang, Chengkun (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Huang, Ketuan (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Wang, Xiangkun (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Han, Chuangye (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Huang, Rui (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hematol, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Liu, Xiaoguang (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangdong Med Univ, Affiliated Hosp, Dept Hepatobiliary Surg, Zhanjiang 524001, Guangdong, Peoples R China.
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- Yu, Long (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Zhengzhou Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Zhengzhou 450000, Henan, Peoples R China.
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- Zhu, Guangzhi (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Su, Hao (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Qin, Wei (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Deng, Jianlong (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 6, Dept Hepatobiliary Surg, Yulin 537000, Guangxi Zhuang, Peoples R China.
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- Zeng, Xianmin (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Han, Bowen (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Han, Quanfa (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Liu, Zhengqian (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Zhou, Xin (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Liu, Junqi (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Gong, Yizhen (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Colorectal & Anal Surg, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 1, Dept Evidence Based Med, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Liu, Zhengtao (author)
- KTH,Science for Life Laboratory, SciLifeLab,Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou 310003, Zhejiang, Peoples R China.;Key Lab Organ Transplantat Zhejiang Prov, Hangzhou 310003, Zhejiang, Peoples R China.
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- Huang, Jianlv (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Guangxi Med Univ, Affiliated Hosp 3, Dept Hepatobiliary Surg, Nanning 530031, Guangxi Zhuang, Peoples R China.
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- Lu, Lei (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.;Peking Univ, Beijing Haidian Sect, Hosp 3, Dept Gen Surg,Beijing Haidian Hosp, Beijing 100080, Peoples R China.
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- Ye, Xinping (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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- Peng, Tao (author)
- Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China.
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Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Shuang Yong Rd 6, Nanning 530021, Guangxi Zhuang, Peoples R China Guangxi Med Univ, Affiliated Hosp 1, Dept Hematol, Nanning 530021, Guangxi Zhuang, Peoples R China. (creator_code:org_t)
- IVYSPRING INT PUBL, 2019
- 2019
- English.
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In: Journal of Cancer. - : IVYSPRING INT PUBL. - 1837-9664. ; 10:23, s. 5689-5704
- Related links:
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https://www.jcancer....
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https://urn.kb.se/re...
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https://doi.org/10.7...
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Abstract
Subject headings
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- Objective: Our study is aim to explore potential key biomarkers and pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) using genome-wide expression profile dataset and methods. Methods: Dataset from the GSE14520 is used as the training cohort and The Cancer Genome Atlas dataset as the validation cohort. Differentially expressed genes (DEGs) screening were performed by the limma package. Gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), gene ontology, the Kyoto Encyclopedia of Genes and Genomes, and risk score model were used for pathway and genes identification. Results: GSEA revealed that several pathways and biological processes are associated with hepatocarcinogenesis, such as the cell cycle, DNA repair, and p53 pathway. A total of 160 DEGs were identified. The enriched functions and pathways of the DEGs included toxic substance decomposition and metabolism processes, and the P450 and p53 pathways. Eleven of the DEGs were identified as hub DEGs in the WGCNA. In survival analysis of hub DEGs, high expression of PRC1 and TOP2A were significantly associated with poor clinical outcome of HBV-related HCC, and shown a good performance in HBV-related HCC diagnosis. The prognostic signature consisting of PRC1 and TOP2A also doing well in the prediction of HBV-related HCC prognosis. The diagnostic and prognostic values of PRC1 and TOP2A was confirmed in TCGA HCC patients. Conclusions: Key biomarkers and pathways identified in the present study may enhance the comprehend of the molecular mechanisms underlying hepatocarcinogenesis. Additionally, mRNA expression of PRC1 and TOP2A may serve as potential diagnostic and prognostic biomarkers for HBV-related HCC.
Subject headings
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Keyword
- hepatitis B virus
- hepatocellular carcinoma
- DNA topoisomerase II alpha
- protein regulator of cytokinesis 1
- prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Liao, Xiwen
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Yu, Tingdong
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Yang, Chengkun
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Huang, Ketuan
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Wang, Xiangkun
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Han, Chuangye
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Huang, Rui
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Liu, Xiaoguang
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Yu, Long
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Zhu, Guangzhi
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Su, Hao
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Qin, Wei
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Deng, Jianlong
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Zeng, Xianmin
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Han, Bowen
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Han, Quanfa
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Liu, Zhengqian
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Zhou, Xin
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Liu, Junqi
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Gong, Yizhen
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Liu, Zhengtao
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Huang, Jianlv
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Lu, Lei
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Ye, Xinping
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Peng, Tao
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Bioinformatics a ...
- Articles in the publication
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Journal of Cance ...
- By the university
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Royal Institute of Technology