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Population structur...
Population structure of drug-resistant Mycobacterium tuberculosis in Central Asia
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- Engström, Anna (författare)
- Uppsala universitet,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Res Ctr Borstel, Mol & Expt Mycobacteriol, Pk Allee 1, D-23845 Borstel, Germany;Sci Life Lab, Clin Genom, Tomtebodavagen 23 A, S-17165 Solna, Sweden;KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, Div Gene Technol, Stockholm, Sweden;Sci Life Lab, Tomtebodavagen 23 A, S-17165 Solna, Sweden
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- Antonenka, Uladzimir (författare)
- IML Red GmbH, WHO Supranatl Reference Lab TB, Inst Microbiol & Lab Med, Robert Koch Allee 2, D-82131 Gauting, Germany
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- Kadyrov, Abdylat (författare)
- Natl TB Inst, 90a Ahuunbaen St, Bishkek 720075, Kyrgyzstan
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- Kalmambetova, Gulmira (författare)
- Natl Reference Lab TB, 90a Ahuunbaen St, Bishkek 720075, Kyrgyzstan
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- Kranzer, Katharina (författare)
- London Sch Hyg & Trop Med, Dept Clin Res, London, England
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- Merker, Matthias (författare)
- Res Ctr Borstel, Mol & Expt Mycobacteriol, Pk Allee 1, D-23845 Borstel, Germany
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- Kabirov, Olim (författare)
- Natl Reference Lab TB, Dushanbe, Tajikistan
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- Parpieva, Nargiza (författare)
- Republican Specialized Sci & Pract Med Ctr TB & P, Alimov Str 1, Tashkent 100086, Uzbekistan
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- Rajabov, Asliddin (författare)
- Natl TB Ctr, Natl TB Program, Dushanbe, Tajikistan
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- Sahalchyk, Evgeni (författare)
- IML Red GmbH, WHO Supranatl Reference Lab TB, Inst Microbiol & Lab Med, Robert Koch Allee 2, D-82131 Gauting, Germany
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- Sayfudtinov, Zayniddin (författare)
- Natl Reference Lab TB, Alimov Str 1, Tashkent 100086, Uzbekistan
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- Niemann, Stefan (författare)
- Res Ctr Borstel, Mol & Expt Mycobacteriol, Pk Allee 1, D-23845 Borstel, Germany
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- Hoffmann, Harald (författare)
- IML Red GmbH, WHO Supranatl Reference Lab TB, Inst Microbiol & Lab Med, Robert Koch Allee 2, D-82131 Gauting, Germany;SYNLAB Human Genet Munich, SYNLAB Gauting, Robert Koch Allee 2, D-82131 Gauting, Germany;Kuratorium TB World eV, Robert Koch Allee 2, D-82131 Gauting, Germany
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(creator_code:org_t)
- 2019-10-29
- 2019
- Engelska.
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Ingår i: BMC Infectious Diseases. - : BMC. - 1471-2334. ; 19:1
- Relaterad länk:
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https://doi.org/10.1...
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https://bmcinfectdis...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Drug-resistant tuberculosis (TB) is a major public health concern threathing the success of TB control efforts, and this is particularily problematic in Central Asia. Here, we present the first analysis of the population structure of Mycobacterium tuberculosis complex isolates in the Central Asian republics Uzbekistan, Tajikistan, and Kyrgyzstan. Methods: The study set consisted of 607 isolates with 235 from Uzbekistan, 206 from Tajikistan, and 166 from Kyrgyzstan. 24-loci MIRU-VNTR (Mycobacterial Interspersed Repetitive Units - Variable Number of Tandem Repeats) typing and spoligotyping were combined for genotyping. In addition, phenotypic drug suceptibility was performed. Results: The population structure mainly comprises strains of the Beijing lineage (411/607). 349 of the 411 Beijing isolates formed clusters, compared to only 33 of the 196 isolates from other clades. Beijing 94-32 (n = 145) and 100-32 (n = 70) formed the largest clusters. Beijing isolates were more frequently multidrug-resistant, pre-extensively resistant (pre-XDR)- or XDR-TB than other genotypes. Conclusions: Beijing clusters 94-32 and 100-32 are the dominant MTB genotypes in Central Asia. The relative size of 100-32 compared to previous studies in Kazakhstan and its unequal geographic distribution support the hypothesis of its more recent emergence in Central Asia. The data also demonstrate that clonal spread of resistant TB strains, particularly of the Beijing lineage, is a root of the so far uncontroled MDR-TB epidemic in Central Asia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Molecular typing
- MIRU
- MDR-TB
- Beijing
- Cluster
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Engström, Anna
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Antonenka, Uladz ...
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Kadyrov, Abdylat
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Kalmambetova, Gu ...
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Kranzer, Kathari ...
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Merker, Matthias
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Kabirov, Olim
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Parpieva, Nargiz ...
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Rajabov, Asliddi ...
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Sahalchyk, Evgen ...
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Sayfudtinov, Zay ...
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Niemann, Stefan
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Hoffmann, Harald
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Mikrobiologi ino ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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BMC Infectious D ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet