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Computational and e...
Computational and experimental characterization of 3D-printed PCL structures toward the design of soft biological tissue scaffolds
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- Liu, Hailong (författare)
- KTH,Polymerteknologi,Hållfasthetslära
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- Ahlinder, Astrid (författare)
- KTH,Polymerteknologi
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Yassin, M. A. (författare)
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- Finne Wistrand, Anna, 1976- (författare)
- KTH,Polymerteknologi
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- Gasser, T. Christian (författare)
- KTH,Hållfasthetslära
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Materials & design. - : Elsevier. - 0264-1275 .- 1873-4197. ; 188
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Degradable porous polymeric structures are attractive candidates for biological tissue scaffolds, and adequate mechanical, transport, chemical and biological properties determine their functionality. Aside from the properties of polymer-based materials, the scaffold's meso-structure controls its elasticity at the organ length-scale. This study investigated the effect of the meso-structure on scaffolds' mechanical and transport properties using finite element analysis (FEA) and computational fluid dynamics (CFD). A number of poly (ε-caprolactone) (PCL) - based scaffolds were 3D printed, analyzed by microcomputed tomography (micro-CT) and mechanically tested. We found that the gradient (G) and gradient and staggered (GS) meso-structure designs led to a higher scaffold permeability, a more homogeneous flow inside the scaffold, and a lower wall shear stress (WSS) in comparison with the basic (B) meso-structure design. The GS design resulted in scaffold stiffness as low as 1.07/0.97 MPa under compression/tension, figures that are comparative with several soft tissues. Image processing of micro-CT data demonstrated that the imposed meso-structures could have been adequately realized through 3D printing, and experimental testing validated FEA analysis. Our results suggest that the properties of 3D-printed PCL-based scaffolds can be tuned via meso-structures toward soft tissue engineering applications. The biological function of designed scaffolds should be further explored in-situ studies.
Ämnesord
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Nyckelord
- 3D printing
- Computational fluid dynamics
- Finite element analysis
- Meso-structure
- Scaffold
- Soft tissue engineering
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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