Sökning: id:"swepub:oai:DiVA.org:kth-269582" >
A System-wide Appro...
-
Ressa, AnnaUniv Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
(författare)
A System-wide Approach to Monitor Responses to Synergistic BRAF and EGFR Inhibition in Colorectal Cancer Cells
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC,2018
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:kth-269582
-
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-269582URI
-
https://doi.org/10.1074/mcp.RA117.000486DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:139290863URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
QC 20200406
-
Intrinsic and/or acquired resistance represents one of the great challenges in targeted cancer therapy. A deeper understanding of the molecular biology of cancer has resulted in more efficient strategies, where one or multiple drugs are adopted in novel therapies to tackle resistance. This beneficial effect of using combination treatments has also been observed in colorectal cancer patients harboring the BRAF(V600E) mutation, whereby dual inhibition of BRAF(V600E) and EGFR increases antitumor activity. Notwithstanding this success, it is not clear whether this combination treatment is the only or most effective treatment to block intrinsic resistance to BRAF inhibitors. Here, we investigate molecular responses upon single and multi-target treatments, over time, using BRAF(V600E) mutant colorectal cancer cells as a model system. Through integration of transcriptomic, proteomic and phosphoproteomics data we obtain a comprehensive overview, revealing both known and novel responses. We primarily observe widespread up-regulation of receptor tyrosine kinases and metabolic pathways upon BRAF inhibition. These findings point to mechanisms by which the drug-treated cells switch energy sources and enter a quiescent-like state as a defensive response, while additionally compensating for the MAPK pathway inhibition.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Bosdriesz, EvertNetherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
(författare)
-
de Ligt, JoepUniv Utrecht, Univ Med Ctr Utrecht, Div Biomed Genet, Ctr Mol Med & Canc Genom Netherlands, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
(författare)
-
Mainardi, SaraNetherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
(författare)
-
Maddalo, GianlucaKTH,Skolan för kemi, bioteknologi och hälsa (CBH),Science for Life Laboratory, SciLifeLab(Swepub:kth)u15e44gj
(författare)
-
Prahallad, AnirudhNetherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.;Novartis Pharma AG, Novartis Inst BioMed Res, CH-4002 Basel, Switzerland.
(författare)
-
Jager, MyrtheUniv Utrecht, Univ Med Ctr Utrecht, Div Biomed Genet, Ctr Mol Med & Canc Genom Netherlands, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
(författare)
-
de la Fonteijne, LisanneUniv Utrecht, Univ Med Ctr Utrecht, Div Biomed Genet, Ctr Mol Med & Canc Genom Netherlands, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
(författare)
-
Fitzpatrick, MartinUniv Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
(författare)
-
Groten, StijnUniv Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
(författare)
-
Altelaar, A. F. MaartenUniv Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
(författare)
-
Bernards, ReneNetherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
(författare)
-
Cuppen, EdwinUniv Utrecht, Univ Med Ctr Utrecht, Div Biomed Genet, Ctr Mol Med & Canc Genom Netherlands, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
(författare)
-
Wessels, LodewykNetherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.;Delft Univ Technol, Dept EEMCS, Mekelweg 4, NL-2628 CD Delft, Netherlands.
(författare)
-
Heck, Albert J. R.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
(författare)
-
Univ Utrecht, Utrecht Inst Pharmaceut Sci, Biomol Mass Spectrometry & Prote Grp, Padualaan 8, NL-3584 CH Utrecht, Netherlands.Netherlands Canc Inst, Oncode Inst, Canc Genom Ctr Netherlands, Div Mol Carcinogenesis, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands.
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Molecular & Cellular Proteomics: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC17:10, s. 1892-19081535-94761535-9484
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ressa, Anna
-
Bosdriesz, Evert
-
de Ligt, Joep
-
Mainardi, Sara
-
Maddalo, Gianluc ...
-
Prahallad, Aniru ...
-
visa fler...
-
Jager, Myrthe
-
de la Fonteijne, ...
-
Fitzpatrick, Mar ...
-
Groten, Stijn
-
Altelaar, A. F. ...
-
Bernards, Rene
-
Cuppen, Edwin
-
Wessels, Lodewyk
-
Heck, Albert J. ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Molecular & Cell ...
- Av lärosätet
-
Kungliga Tekniska Högskolan
-
Karolinska Institutet