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Ouabain protects ag...
Ouabain protects against adverse developmental programming of the kidney
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Li, Juan (författare)
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- Khodus, Georgiy R. (författare)
- Karolinska Institutet
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- Kruusmagi, Markus (författare)
- Karolinska Institutet
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- Kamali-Zare, Padideh (författare)
- KTH,Cellens fysik
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Liu, Xiao-Li (författare)
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Eklöf, Ann-Christine (författare)
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- Zelenin, Sergey (författare)
- Karolinska Institutet
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- Brismar, Hjalmar (författare)
- Karolinska Institutet,KTH,Cellens fysik
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- Aperia, Anita (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2010-07-27
- 2010
- Engelska.
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 1, s. 42-
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The kidney is extraordinarily sensitive to adverse fetal programming. Malnutrition, the most common form of developmental challenge, retards the formation of functional units, the nephrons. The resulting low nephron endowment increases susceptibility to renal injury and disease. Using explanted rat embryonic kidneys, we found that ouabain, the Na, K-ATPase ligand, triggers a calcium-nuclear factor-kappa B signal, which protects kidney development from adverse effects of malnutrition. To mimic malnutrition, kidneys were serum deprived for 24 h. This resulted in severe retardation of nephron formation and a robust increase in apoptosis. In ouabain-exposed kidneys, no adverse effects of serum deprivation were observed. Proof of principle that ouabain rescues development of embryonic kidneys exposed to malnutrition was obtained from studies on pregnant rats given a low-protein diet and treated with ouabain or vehicle throughout pregnancy. Thus, we have identified a survival signal and a feasible therapeutic tool to prevent adverse programming of kidney development.
Ämnesord
- NATURVETENSKAP -- Fysik -- Den kondenserade materiens fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Condensed Matter Physics (hsv//eng)
Nyckelord
- NA-K-ATPASE
- NF-KAPPA-B
- PROXIMAL TUBULAR CELLS
- LOW-BIRTH-WEIGHT
- CALCIUM OSCILLATIONS
- RENAL-DISEASE
- GLOMERULAR NUMBER
- HYPERTENSION
- NEPHRON
- RESTRICTION
- MEDICINE
- MEDICIN
- Biological physics
- Biologisk fysik
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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