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Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis

Eriksson, Kaja (författare)
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
Fei, Guozhong (författare)
Acad Specialist Ctr, Ctr Rheumatol, Stockholm Hlth Serv, S-10235 Stockholm, Sweden.,Center for Rheumatology, Academic Specialist Center, Stockholm Health Services, 10235 Stockholm, Sweden
Lundmark, Anna (författare)
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
visa fler...
Benchimol, Daniel (författare)
Karolinska Institutet
Lee, Linkiat (författare)
Karolinska Institutet
Hu, Yue O. O. (författare)
Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH),Science for Life Laboratory School of Biotechnology, KTH Royal Institute of Technology, 17121 Stockholm, Sweden; Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, 17164 Stockholm, Sweden
Kats, Anna (författare)
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
Saevarsdottir, Saedis (författare)
Karolinska Institutet
Catrina, Anca Irinel (författare)
Karolinska Institutet
Klinge, Björn (författare)
Karolinska Institutet,Malmö universitet,Odontologiska fakulteten (OD),Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden
Andersson, Anders F. (författare)
KTH,Science for Life Laboratory, SciLifeLab,Skolan för kemi, bioteknologi och hälsa (CBH),Science for Life Laboratory School of Biotechnology, KTH Royal Institute of Technology, 17121 Stockholm, Sweden
Klareskog, Lars (författare)
Karolinska Univ Hosp, Dept Med, Rheumatol Unit, S-17176 Stockholm, Sweden.,Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Solna, 17176 Stockholm, Sweden
Lundberg, Karin (författare)
Karolinska Institutet
Jansson, Leif (författare)
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden.;Stockholm Cty Council, Eastmaninst, Dept Periodontol, S-11382 Stockholm, Sweden.,Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden; Department of Periodontology at Eastmaninstitutet, Stockholm County Council, 11382 Stockholm, Sweden
Yucel-Lindberg, Tulay (författare)
Karolinska Institutet
visa färre...
Karolinska Inst, Dept Dent Med, Div Periodontol, S-14104 Huddinge, Sweden Department of Dental Medicine, Division of Periodontology, Karolinska Institutet, 14104 Huddinge, Sweden (creator_code:org_t)
2019-05-08
2019
Engelska.
Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:5
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection of blood, saliva, gingival crevicular fluid (GCF) and subgingival plaque. Composition of plaque and saliva microbiota were analysed using 16S rRNA sequencing and levels of inflammatory mediators by multiplex-immunoassay. The majority of the patients (75%) had moderate or severe periodontitis and the rest had no/mild periodontitis. Anti-citrullinated protein antibody (ACPA) positivity was significantly more frequent in the moderate/severe periodontitis (86%) compared to the no/mild group (50%). No significance between groups was observed for RA disease duration or activity, or type of medication. Levels of sCD30/TNFRSF8, IFN-2, IL-19, IL-26, MMP-1, gp130/sIL-6R ss, and sTNF-R1 were significantly higher in serum or GCF, and April/TNFSF13 was significantly higher in serum and saliva samples in moderate/severe periodontitis. The microbial composition in plaque also differed significantly between the two groups. In conclusion, the majority of RA patients had moderate/severe periodontitis and that this severe form of the disease was significantly associated with ACPA positivity, an altered subgingival microbial profile, and increased levels of systemic and oral inflammatory mediators.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dentistry (hsv//eng)

Nyckelord

rheumatoid arthritis
periodontitis
periodontal disease
anti-citrullinated protein autoantibodies
rheumatoid factor
smoking
medication
Porphyromonas gingivalis

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