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The microcircuits o...
The microcircuits of striatum in silico
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- Hjorth, J. J. Johannes (author)
- KTH,Science for Life Laboratory, SciLifeLab,Skolan för elektroteknik och datavetenskap (EECS)
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- Kozlov, Alexander (author)
- Karolinska Institutet,KTH,Skolan för elektroteknik och datavetenskap (EECS),Science for Life Laboratory, SciLifeLab,Karolinska Inst, Dept Neurosci, SE-17165 Stockholm, Sweden.
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- Carannante, Ilaria (author)
- KTH,Beräkningsvetenskap och beräkningsteknik (CST),Science for Life Laboratory, SciLifeLab
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- Nylen, Johanna Frost (author)
- Karolinska Inst, Dept Neurosci, SE-17165 Stockholm, Sweden.
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- Lindroos, Robert (author)
- Karolinska Institutet
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- Johansson, Yvonne (author)
- Karolinska Institutet
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- Tokarska, Anna (author)
- Karolinska Institutet
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- Dorst, Matthijs C. (author)
- Karolinska Institutet
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- Suryanarayana, Shreyas M. (author)
- Karolinska Institutet
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- Silberberg, Gilad (author)
- Karolinska Institutet
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- Hellgren Kotaleski, Jeanette (author)
- KTH,Science for Life Laboratory, SciLifeLab,Skolan för elektroteknik och datavetenskap (EECS),Karolinska Inst, Dept Neurosci, SE-17165 Stockholm, Sweden.
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- Grillner, Sten (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-04-22
- 2020
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:17, s. 9554-9565
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Abstract
Subject headings
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- The basal ganglia play an important role in decision making and selection of action primarily based on input from cortex, thalamus, and the dopamine system. Their main input structure, striatum, is central to this process. It consists of two types of projection neurons, together representing 95% of the neurons, and 5% of interneurons, among which are the cholinergic, fast-spiking, and low threshold-spiking subtypes. The membrane properties, somadendritic shape, and intrastriatal and extrastriatal synaptic interactions of these neurons are quite well described in the mouse, and therefore they can be simulated in sufficient detail to capture their intrinsic properties, as well as the connectivity. We focus on simulation at the striatal cellular/microcircuit level, in which the molecular/subcellular and systems levels meet. We present a nearly full-scale model of the mouse striatum using available data on synaptic connectivity, cellular morphology, and electrophysiological properties to create a microcircuit mimicking the real network. A striatal volume is populated with reconstructed neuronal morphologies with appropriate cell densities, and then we connect neurons together based on appositions between neurites as possible synapses and constrain them further with available connectivity data. Moreover, we simulate a subset of the striatum involving 10,000 neurons, with input from cortex, thalamus, and the dopamine system, as a proof of principle. Simulation at this biological scale should serve as an invaluable tool to understand the mode of operation of this complex structure. This platform will be updated with new data and expanded to simulate the entire striatum.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- modeling
- basal ganglia
- network
- compartmental models
- computational analysis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hjorth, J. J. Jo ...
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Kozlov, Alexande ...
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Carannante, Ilar ...
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Nylen, Johanna F ...
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Lindroos, Robert
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Johansson, Yvonn ...
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Tokarska, Anna
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Dorst, Matthijs ...
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Suryanarayana, S ...
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Silberberg, Gila ...
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Hellgren Kotales ...
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Grillner, Sten
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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Proceedings of t ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet