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Molecular Profiling...
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer
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- Drobin, Kimi (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Halle, Martin (author)
- Karolinska Institutet
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- Danielsson, Daniel (author)
- Karolinska Institutet
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- Papiez, Anna (author)
- Silesian Tech Univ, Dept Data Sci & Engn, Gliwice 44100, Poland.
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- Sangsuwan, Traimate (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Ctr Radiat Protect Res, Stockholm 10691, Sweden.
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- Bendes, Annika (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Hong, Mun-Gwan (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Qundos, Ulrika (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Harms-Ringdahl, Mats (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Ctr Radiat Protect Res, Stockholm 10691, Sweden.
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- Wersall, Peter (author)
- Karolinska Univ Hosp, Dept Radiotherapy, Stockholm 17176, Sweden.
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- Polanska, Joanna (author)
- Silesian Tech Univ, Dept Data Sci & Engn, Gliwice 44100, Poland.
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Haghdoost, Siamak (author)
- Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University of Caen Normandy, France,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Ctr Radiat Protect Res, Stockholm 10691, Sweden.;Univ Caen Normandy, Adv Resource Ctr HADrontherapy Europe ARCHADE, Cimap Laria, Dept Med, Caen 14076, France.
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(creator_code:org_t)
- 2020-03-22
- 2020
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 12:3
- Related links:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
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- Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importance for cancer patients with long-term survival, may appear during or long time after finishing radiotherapy and depending on the patient's radiosensitivity. Currently, there is no assay available that can reliably predict the individual's response to radiotherapy. We profiled two study sets from breast (n = 29) and head-and-neck cancer patients (n = 74) that included radiosensitive patients and matched radioresistant controls. We studied 55 single nucleotide polymorphisms (SNPs) in 33 genes by DNA genotyping and 130 circulating proteins by affinity-based plasma proteomics. In both study sets, we discovered several plasma proteins with the predictive power to find radiosensitive patients (adjusted p < 0.05) and validated the two most predictive proteins (THPO and STIM1) by sandwich immunoassays. By integrating genotypic and proteomic data into an analysis model, it was found that the proteins CHIT1, PDGFB, PNKD, RP2, SERPINC1, SLC4A, STIM1, and THPO, as well as the VEGFA gene variant rs69947, predicted radiosensitivity of our breast cancer (AUC = 0.76) and head-and-neck cancer (AUC = 0.89) patients. In conclusion, circulating proteins and a SNP variant of VEGFA suggest that processes such as vascular growth capacity, immune response, DNA repair and oxidative stress/hypoxia may be involved in an individual's risk of experiencing radiation-induced toxicity.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Medicinsk bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- radiosensitivity
- prediction
- plasma proteins
- radiotherapy
- breast cancer
- head-and-neck cancer
- skin reaction
- biomarker
- mandibular osteoradionecrosis
- ionizing radiation
- radiotherapy side effects
- personalized radiotherapy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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To the university's database
- By the author/editor
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Drobin, Kimi
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Schwenk, Jochen ...
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Halle, Martin
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Danielsson, Dani ...
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Papiez, Anna
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Sangsuwan, Traim ...
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show more...
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Bendes, Annika
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Hong, Mun-Gwan
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Qundos, Ulrika
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Harms-Ringdahl, ...
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Wersall, Peter
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Polanska, Joanna
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Haghdoost, Siama ...
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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and Medical Biotechn ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancers
- By the university
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Royal Institute of Technology
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Stockholm University
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Karolinska Institutet