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> (2020-2024) >
Nanoassembled Pepti...
Abstract
Ämnesord
Stäng
- Early detection of cancer is likely to be one of the most effective means of reducing the cancer mortality rate. Hence, simple and ultra-quick methods for noninvasive detection of early-stage tumors are highly sought-after. In this study, a nanobiosensing platform with a rapid response time of nearly 30 s is introduced for the detection of matrilysin—the salivary gland cancer biomarker—with a limit of detection as low as 30 nm. This sensing platform is based on matrilysin-digestible peptides that bridge gold nanoparticle (AuNPs) cores (≈30–50 nm) and carbon quantum dot (CDs) satellites (≈9 nm). A stepwise synthesis procedure is used for self-assembly of AuNP-peptide-CDs, ensuring their long-term stability. The AuNP-peptide-CDs produce ideal optical signals, with noticeable fluorescence quenching effects. Upon peptide cleavage by matrilysin, CDs leave the surface of AuNPs, resulting in ultra-fast detectable violet and visible fluorescent signals.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Nyckelord
- hybrid architectures
- matrilysin
- nanobiosensors
- optical sensing
- sensing platforms
- tumor detection
- Biomarkers
- Carbon Quantum Dots
- Diseases
- Fluorescence
- Gold nanoparticles
- Quenching
- Self assembly
- Semiconductor quantum dots
- Tumors
- Nano-biosensors
- Peptides
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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