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  • Ji, Andrew L.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA. (author)

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Cell Press,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-279217
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279217URI
  • https://doi.org/10.1016/j.cell.2020.05.039DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20200818
  • To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin. cSCC exhibited four tumor subpopulations, three recapitulating normal epidermal states, and a tumor-specific keratinocyte (TSK) population unique to cancer, which localized to a fibrovascular niche. Integration of single-cell and spatial data mapped ligand-receptor networks to specific cell types, revealing TSK cells as a hub for intercellular communication. Multiple features of potential immunosuppression were observed, including T regulatory cell (Treg) co-localization with CD8 T cells in compartmentalized tumor stroma. Finally, single-cell characterization of human tumor xenografts and in vivo CRISPR screens identified essential roles for specific tumor subpopulation-enriched gene networks in tumorigenesis. These data define cSCC tumor and stromal cell subpopulations, the spatial niches where they interact, and the communicating gene networks that they engage in cancer.

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  • Rubin, Adam J.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Thrane, KimKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1uojhlo (author)
  • Jiang, SizunStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. (author)
  • Reynolds, David L.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Meyers, Robin M.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Guo, Margaret G.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • George, Benson M.Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Sch Med, Stanford, CA 94305 USA. (author)
  • Mollbrink, AnnelieKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u18ttoxc (author)
  • Bergenstråhle, JosephKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ck6nue (author)
  • Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u13lw4hm (author)
  • Bai, YunhaoStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. (author)
  • Zhu, BokaiStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. (author)
  • Bhaduri, AparnaUniv Calif San Francisco UCSF, Dept Neurol, San Francisco, CA 94122 USA. (author)
  • Meyers, Jordan M.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Rovira-Clave, XavierStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. (author)
  • Hollmig, S. TylerStanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Aasi, Sumaira Z.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (author)
  • Nolan, Garry P.Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. (author)
  • Lundeberg, JoakimKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1qkn9kw (author)
  • Khavari, Paul A.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.;Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA. (author)
  • Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA. (creator_code:org_t)

Related titles

  • In:Cell: Cell Press182:2, s. 497-+0092-86741097-4172

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