Search: id:"swepub:oai:DiVA.org:kth-279217" >
Multimodal Analysis...
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Ji, Andrew L.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.
(author)
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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Cell Press,2020
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-279217
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279217URI
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https://doi.org/10.1016/j.cell.2020.05.039DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20200818
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To define the cellular composition and architecture of cutaneous squamous cell carcinoma (cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and multiplexed ion beam imaging from a series of human cSCCs and matched normal skin. cSCC exhibited four tumor subpopulations, three recapitulating normal epidermal states, and a tumor-specific keratinocyte (TSK) population unique to cancer, which localized to a fibrovascular niche. Integration of single-cell and spatial data mapped ligand-receptor networks to specific cell types, revealing TSK cells as a hub for intercellular communication. Multiple features of potential immunosuppression were observed, including T regulatory cell (Treg) co-localization with CD8 T cells in compartmentalized tumor stroma. Finally, single-cell characterization of human tumor xenografts and in vivo CRISPR screens identified essential roles for specific tumor subpopulation-enriched gene networks in tumorigenesis. These data define cSCC tumor and stromal cell subpopulations, the spatial niches where they interact, and the communicating gene networks that they engage in cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rubin, Adam J.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Thrane, KimKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1uojhlo
(author)
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Jiang, SizunStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
(author)
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Reynolds, David L.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Meyers, Robin M.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Guo, Margaret G.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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George, Benson M.Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Sch Med, Stanford, CA 94305 USA.
(author)
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Mollbrink, AnnelieKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u18ttoxc
(author)
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Bergenstråhle, JosephKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ck6nue
(author)
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Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u13lw4hm
(author)
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Bai, YunhaoStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
(author)
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Zhu, BokaiStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
(author)
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Bhaduri, AparnaUniv Calif San Francisco UCSF, Dept Neurol, San Francisco, CA 94122 USA.
(author)
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Meyers, Jordan M.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Rovira-Clave, XavierStanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
(author)
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Hollmig, S. TylerStanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Aasi, Sumaira Z.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(author)
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Nolan, Garry P.Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA.
(author)
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Lundeberg, JoakimKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1qkn9kw
(author)
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Khavari, Paul A.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.;Vet Affairs Palo Alto Healthcare Syst, Palo Alto, CA 94304 USA.
(author)
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Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Canc Inst, Sch Med, Stanford, CA 94305 USA.Stanford Univ, Program Epithelial Biol, Sch Med, Stanford, CA 94305 USA.
(creator_code:org_t)
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In:Cell: Cell Press182:2, s. 497-+0092-86741097-4172
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Ji, Andrew L.
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Rubin, Adam J.
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Thrane, Kim
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Jiang, Sizun
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Reynolds, David ...
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Meyers, Robin M.
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Guo, Margaret G.
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George, Benson M ...
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Mollbrink, Annel ...
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Bergenstråhle, J ...
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Larsson, Ludvig
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Bai, Yunhao
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Zhu, Bokai
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Bhaduri, Aparna
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Meyers, Jordan M ...
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Rovira-Clave, Xa ...
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Hollmig, S. Tyle ...
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Aasi, Sumaira Z.
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Nolan, Garry P.
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Lundeberg, Joaki ...
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Khavari, Paul A.
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- MEDICAL AND HEALTH SCIENCES
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Cell
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Royal Institute of Technology