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  • Chen, Wei-TingVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • Elsevier BV,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-281143
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-281143URI
  • https://doi.org/10.1016/j.cell.2020.06.038DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20201007
  • Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer's disease (AD), little is known about the molecular changes and cellular interactions that characterize this response, We investigate here, in an AD mouse model, the transcriptional changes occurring in tissue domains in a 100-mu m diameter around amyloid plaques using spatial transcriptomics. We demonstrate early alterations in a gene co-expression network enriched for myelin and oligodendrocyte genes (OLIGs), whereas a multicellular gene co-expression network of plaque-induced genes (PIGs) involving the complement system, oxidative stress, lysosomes, and inflammation is prominent in the later phase of the disease. We confirm the majority of the observed alterations at the cellular level using in situ sequencing on mouse and human brain sections. Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lu, AshleyVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Craessaerts, KatleenVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Pavie, BenjaminVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium. (author)
  • Frigerio, Carlo SalaVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England. (author)
  • Corthout, NikkyVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium. (author)
  • Qian, XiaoyanCartana AB, Nobels Vag 16, S-17165 Solna, Sweden. (author)
  • Lalakova, JanaCartana AB, Nobels Vag 16, S-17165 Solna, Sweden. (author)
  • Kuhnemund, MalteCartana AB, Nobels Vag 16, S-17165 Solna, Sweden. (author)
  • Voytyuk, IrynaVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Wolfs, LeenVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Mancuso, RenzoVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Salta, EvgeniaVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Balusu, SriramVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Snellinx, AnVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium. (author)
  • Munck, SebastianVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium. (author)
  • Jurek, AleksandraKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1qtfp9v (author)
  • Fernandez Navarro, JoseKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11gbovc (author)
  • Saido, Takaomi C.RIKEN Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan. (author)
  • Huitinga, IngeRoyal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Neuroimmunol, NL-1105 BA Amsterdam, Netherlands.;Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 XH Amsterdam, Netherlands. (author)
  • Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1qkn9kw (author)
  • Fiers, MarkVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England. (author)
  • De Strooper, BartVIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England. (author)
  • VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium. (creator_code:org_t)

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  • In:Cell: Elsevier BV182:4, s. 976-+0092-86741097-4172

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