Search: L773:1610 2940 OR L773:0948 5023
> (2010-2014) >
Generation of solub...
Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease : A DFT study
-
- Haeffner, Fredrik (author)
- KTH,Fysikalisk kemi
-
Barnham, Kevin J. (author)
-
Bush, Ashley I. (author)
-
show more...
-
- Brinck, Tore (author)
- KTH,Fysikalisk kemi
-
show less...
-
(creator_code:org_t)
- 2009-11-20
- 2010
- English.
-
In: Journal of Molecular Modeling. - : Springer Science and Business Media LLC. - 1610-2940 .- 0948-5023. ; 16:6, s. 1103-1108
- Related links:
-
https://hal.archives...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- A mechanism for the oxidation of a dimeric beta-amyloid copper ion complex is proposed based on DFT calculations. It involves the Met35 residue, which is believed to be important in the neurotoxicity causing Alzheimer's disease. Oxidation of Met35 is found to proceed readily with dioxygen when two Met35 residues are close to each other and the copper ion. This indicates that oxidants, such as hydrogen peroxide, are not necessary for oxidation of beta-amyloid copper ion complexes. Understanding these processes could be pivotal in gaining more knowledge of this complex disease and for the development of therapeutic treatments.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Keyword
- Alzheimer's disease
- beta-amyloid
- Copper ion
- Met35
- Molecular modeling
- Oxidation
- Chemistry
- Kemi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database