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Biocompliant Compos...
Biocompliant Composite Au/pHEMA Plasmonic Scaffolds for 3D Cell Culture and Noninvasive Sensing of Cellular Metabolites
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2020-09-09
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Wiley-VCH Verlag,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-284910
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-284910URI
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https://doi.org/10.1002/adhm.202001040DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20201209In press
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The field of 3D printing is an area of active research, with a substantial focus given to the design and construction of customized tools for applications in technology. There exists a particular need in these developing areas of opportunity for new multi-functional soft materials that are biologically compatible for the growth and directed culturing of cells. Herein, a composite material consisting of gold nanoparticles with useful plasmonic properties embedded within a highly hydrophilic poly-2-hydroxyethylmethacrylate matrix is described and characterized. This composite material serves dual functions as both host framework scaffold for cell lines such as pre-osteoblasts as well as a plasmonic biosensor for in situ measurements of living cells. The plasmonic properties of this system are characterized as a function of the material properties and related to compositional features of the material through a proposed light-directed mechanism. This chemistry provides a tunable, 3D printable plasmonic composite material of encapsulated gold nanoparticles in a biologically-compliant, acrylate-based hydrogel matrix. Surface-enhanced Raman scattering studies of 3D-microcultures supported by the scaffolds are carried out and the strong influence of perm-selective molecular diffusion in its analytical responses is established. Most notably, specific, largely hydrophilic, cellular metabolites are detected within the supported live cultures.
Ämnesord och genrebeteckningar
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NATURVETENSKAP Fysik Den kondenserade materiens fysik hsv//swe
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NATURAL SCIENCES Physical Sciences Condensed Matter Physics hsv//eng
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3D printers
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3D printing
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Cell culture
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Cells
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Cellular metabolites
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Composite materials
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Compositional features
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Design and construction
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Fiber optic sensors
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Gold nanoparticles
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Hydrophilicity
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Hydroxyethylmethacrylate
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Metabolites
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Metal nanoparticles
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Non-invasive sensing
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Plasmonic biosensors
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Plasmonic nanoparticles
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Plasmonic properties
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Plasmonics
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Raman scattering
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SERS
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Scaffolds (biology)
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Soft materials
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Surface enhanced Raman Scattering (SERS)
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Surface scattering
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bio-compliant
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biomimetics
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gels
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plasmonic sensing
Biuppslag (personer, institutioner, konferenser, titlar ...)
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McCracken, J M
(författare)
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Miller, L A
(författare)
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Jayalath, S
(författare)
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Nuzzo, Ralph G.KTH,Yt- och korrosionsvetenskap(Swepub:kth)u14f4mg7
(författare)
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KTHYt- och korrosionsvetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Advanced Healthcare Materials: Wiley-VCH Verlag2192-26402192-2659
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