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Ingestible transien...
Ingestible transiently anchoring electronics for microstimulation and conductive signaling
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- Abramson, Alex (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Stanford Univ, 443 Via Ortega, Stanford, CA 94305 USA.
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- Dellal, David (författare)
- MIT, Dept Mech Engn, Cambridge, MA 02139 USA.;Yale Univ, 333 Cedar St, New Haven, CT 06510 USA.
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- Kong, Yong Lin (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Univ Utah, Dept Mech Engn, Salt Lake City, UT 84112 USA.
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- Zhou, Jianlin (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Cornell Univ, Phillips Hall,106 Hoy Rd, Ithaca, NY 14853 USA.
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- Gao, Yuan (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Collins, Joy (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Tamang, Siddartha (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Wainer, Jacob (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Fractyl Labs Inc, 17 Hartwell Ave, Lexington, MA 02421 USA.
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- McManus, Rebecca (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Hayward, Alison (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Div Comparat Med, Cambridge, MA 02139 USA.
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- Frederiksen, Morten Revsgaard (författare)
- Novo Nordisk AS, Global Res Technol & Device R&D, Malov, Denmark.
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- Water, Jorrit J. (författare)
- Novo Nordisk AS, Global Res Technol & Device R&D, Malov, Denmark.
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- Jensen, Brian (författare)
- Novo Nordisk AS, Global Res Technol & Device R&D, Malov, Denmark.
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- Roxhed, Niclas (författare)
- KTH,Mikro- och nanosystemteknik,MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Langer, Robert (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
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- Traverso, Giovanni (författare)
- MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.
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MIT, Dept Chem Engn, Cambridge, MA 02139 USA;MIT, David H Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA.;Stanford Univ, 443 Via Ortega, Stanford, CA 94305 USA. MIT, Dept Mech Engn, Cambridge, MA 02139 USA.;Yale Univ, 333 Cedar St, New Haven, CT 06510 USA. (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2020
- 2020
- Engelska.
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Ingår i: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 6:35
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Ingestible electronic devices enable noninvasive evaluation and diagnosis of pathologies in the gastrointestinal (GI) tract but generally cannot therapeutically interact with the tissue wall. Here, we report the development of an orally administered electrical stimulation device characterized in ex vivo human tissue and in in vivo swine models, which transiently anchored itself to the stomach by autonomously inserting electrically conductive, hooked probes. The probes provided stimulation to the tissue via timed electrical pulses that could be used as a treatment for gastric motility disorders. To demonstrate interaction with stomach muscle tissue, we used the electrical stimulation to induce acute muscular contractions. Pulses conductively signaled the probes' successful anchoring and detachment events to a parenterally placed device. The ability to anchor into and electrically interact with targeted GI tissues controlled by the enteric nervous system introduces opportunities to treat a multitude of associated pathologies.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
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Abramson, Alex
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Dellal, David
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Kong, Yong Lin
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Zhou, Jianlin
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Gao, Yuan
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Collins, Joy
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visa fler...
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Tamang, Siddarth ...
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Wainer, Jacob
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McManus, Rebecca
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Hayward, Alison
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Frederiksen, Mor ...
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Water, Jorrit J.
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Jensen, Brian
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Roxhed, Niclas
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Langer, Robert
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Traverso, Giovan ...
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