SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Jönsson Björn)
 

Sökning: WFRF:(Jönsson Björn) > Comprehensive analy...

Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer

Salomonsson, Annette (författare)
Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
Micke, Patrick (författare)
Uppsala universitet,Klinisk och experimentell patologi,Patrick Micke
Jönsson, Mats (författare)
Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
visa fler...
La Fleur, Linnéa (författare)
Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
Isaksson, J. (författare)
Uppsala University,Gävle Hospital,Uppsala University Hospital,Uppsala Univ, Uppsala Univ Hosp, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Gävle Cent Hosp, Dept Resp Med, Gävle, Sweden.;Uppsala Univ, Cty Council Gävleborg, Ctr Res & Dev, Gävle, Sweden.
Jönsson, M. (författare)
Nodin, Björn (författare)
Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
Botling, Johan (författare)
Uppsala universitet,Klinisk och experimentell patologi,Johan Botling
Uhlén, Mathias (författare)
Stockholm University,KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Albanova VinnExcellence Center for Protein Technology, ProNova,Systembiologi,Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.;Royal Inst Technol, Sch Biotechnol, AlbaNova Univ Ctr, Stockholm, Sweden.
Jirström, Karin (författare)
Lund University,Lunds universitet,Terapeutisk patologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Therapeutic pathology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.;Lab Med Reg Skane, Dept Genet & Pathol, SE-22185 Lund, Sweden.
Staaf, Johan (författare)
Uppsala universitet,Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Klinisk och experimentell patologi,Patrick Micke,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.
Planck, Maria (författare)
Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.;Skane Univ Hosp, Dept Resp Med & Allergol, Lund, Sweden.
Brunnström, Hans (författare)
Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden.;Lab Med Reg Skane, Dept Genet & Pathol, SE-22185 Lund, Sweden.
visa färre...
 (creator_code:org_t)
2020-06-03
2020
Engelska.
Ingår i: Cancer Medicine. - : Blackwell Publishing Ltd. - 2045-7634. ; 9:15, s. 5609-5619
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://onlinelibrar...
http://dx.doi.org/10... (free)
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
https://urn.kb.se/re...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Aims High expression of the RNA-binding motif protein 3 (RBM3) correlates with improved prognosis in several major types of cancer. The aim of the present study was to examine the prognostic value of RBM3 protein and mRNA expression in non-small cell lung cancer (NSCLC).Methods and results Immunohistochemical expression of RBM3 was evaluated in surgically treated NSCLC from two independent patient populations (n = 213 and n = 306). Staining patterns were correlated with clinicopathological parameters, overall survival (OS), and recurrence-free interval (RFI). Cases with high nuclear RBM3 protein expression had a prolonged 5-year OS in both cohorts when analyzing adenocarcinomas separately (P = .02 and P = .01). RBM3 remained an independent prognostic factor for OS in multivariable analysis of cohort I (HR 0.44, 95% CI 0.21-0.90) and for RFI in cohort II (HR 0.38, 95% CI 0.22-0.74). In squamous cell carcinoma, there was instead an insignificant association to poor prognosis. Also, the expression levels of RBM3 mRNA were investigated in 2087 lung adenocarcinomas and 899 squamous cell carcinomas assembled from 13 and 8 public gene expression microarray datasets, respectively. The RBM3 mRNA levels were not clearly associated with patient outcome in either adenocarcinomas or squamous cell carcinomas.Conclusions The results from this study support that high protein expression of RBM3 is linked to improved outcome in lung adenocarcinoma.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Nyckelord

biomarker
gene expression
immunohistochemistry
survival
tissue microarray
RNA binding motif protein 3
RNA binding protein
unclassified drug
adult
aged
Article
cancer prognosis
cancer recurrence
female
human
human tissue
lung adenocarcinoma
major clinical study
male
mRNA expression level
non small cell lung cancer
overall survival
priority journal
protein expression
retrospective study
squamous cell lung carcinoma
biomarker
gene expression
immunohistochemistry
survival
tissue microarray
Pathology

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy