Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson’s Disease

QCR 202007
Background: Cognitive impairment is common in patients with PD. Core markers of Alzheimer’s dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date. Objectives: The aim of this study was to investigate CSF markers associated with cognition in early PD. Methods: A high-throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini-Mental State Examination. Results: Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen-1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders. Conclusions: Kininogen-1 levels in CSF may serve as a marker of cognitive impairment in PD.

Bergström, SofiaKTH,Affinitets-proteomik(Swepub:kth)u1ugb8pi (author)
Tsitsi, P.Karolinska Institutet (author)
Remnestål, JuliaKTH,Affinitets-proteomik(Swepub:kth)u13wztpi (author)
Månberg, Anna,1985-KTH,Affinitets-proteomik(Swepub:kth)u1g5roxd (author)
Hertz, E. (author)
Paslawski, W.Karolinska Institutet (author)
Sorjonen, K.Karolinska Institutet (author)
Uhlén, MathiasDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden(Swepub:kth)u1dulvmw (author)
Mangone, G. (author)
Carvalho, S. (author)
Rascol, O. (author)
Meissner, W. G. (author)
Magnin, E. (author)
Wüllner, U. (author)
Corvol, J. -C (author)
Nilsson, PeterKTH,Affinitets-proteomik(Swepub:kth)u1ws88sk (author)
Svenningsson, P.Karolinska Institutet (author)
Karolinska InstitutetAffinitets-proteomik (creator_code:org_t)

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.