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Clear mortality gap...
Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation
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- Liu, Zhengtao (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.
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- Wang, Wenchao (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.
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- Zhuang, Li (författare)
- Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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- Liu, Jingfeng (författare)
- Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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- Que, Shuping (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Dingxiang Clin, Hangzhou, Peoples R China.
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- Zhu, Dan (författare)
- Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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- Dong, Linfang (författare)
- Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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- Yu, Jian (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.
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- Zhou, Lin (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.
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- Zheng, Shusen (författare)
- Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China.;Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Hangzhou, Peoples R China.
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Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med, Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Peoples R China. Zhejiang Univ, Affiliated Hosp 1, Sch Med, Div Hepatobiliary & Pancreat Surg,Dept Surg, Hangzhou 310003, Peoples R China.;Zhejiang Univ, Affiliated Hosp 1, Sch Med,CAMS, NHC Key Lab Combined Multiorgan Transplantat,Key, Hangzhou, Peoples R China. (creator_code:org_t)
- 2020-12
- 2020
- Engelska.
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Ingår i: Hepatobiliary surgery and nutrition. - : AME Publishing Company. - 2304-3881 .- 2304-389X. ; 9:6, s. 739-758
- Relaterad länk:
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https://hbsn.amegrou...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis is a contributor for inferior graft quality. But its impact and safety on transplantation was less assessed in Chinese patients. Methods: Graft steatosis and related information involved in recipients, donors and surgical procedures were retrospectively collected from 239 patients. Results: Donor macrosteatosis (MaS) caused about 2.14 and 2.80 folds of increment on patient and graft mortality. Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10% (P<0.05). Noteworthy, deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase (ALT, 64%). However, microsteatosis (MiS) grafts didn't affect outcomes after LT. In a cohort of Chinese patients, MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%. Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury. Conclusions: Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients. Further study is worthy to validate these results and investigate inner mechanism under the phenomenon.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Steatosis
- prognosis
- liver transplantation (LT)
- dose-response analysis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Liu, Zhengtao
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Wang, Wenchao
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Zhuang, Li
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Liu, Jingfeng
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Que, Shuping
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Zhu, Dan
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visa fler...
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Dong, Linfang
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Yu, Jian
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Zhou, Lin
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Zheng, Shusen
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Hepatobiliary su ...
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