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Micro- to Nanoscale...
Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation
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- Dispenza, Clelia (author)
- Univ Palermo, Dipartimento Ingn, Viale Sci 6, I-90128 Palermo, Italy.;CNR, Ist Biofis, Via U La Malfa 153, I-90146 Palermo, Italy.
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- Giacomazza, Daniela (author)
- CNR, Ist Biofis, Via U La Malfa 153, I-90146 Palermo, Italy.
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- Jonsson, Mats, 1967- (author)
- KTH,Kemi
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Univ Palermo, Dipartimento Ingn, Viale Sci 6, I-90128 Palermo, Italy;CNR, Ist Biofis, Via U La Malfa 153, I-90146 Palermo, Italy. CNR, Ist Biofis, Via U La Malfa 153, I-90146 Palermo, Italy. (creator_code:org_t)
- 2020-12-31
- 2021
- English.
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In: Biomolecules. - : MDPI. - 2218-273X. ; 11:1
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https://doi.org/10.3...
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Abstract
Subject headings
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- Bio-hybrid hydrogels consist of a water-swollen hydrophilic polymer network encapsulating or conjugating single biomolecules, or larger and more complex biological constructs like whole cells. By modulating at least one dimension of the hydrogel system at the micro- or nanoscale, the activity of the biological component can be extremely upgraded with clear advantages for the development of therapeutic or diagnostic micro- and nano-devices. Gamma or e-beam irradiation of polymers allow a good control of the chemistry at the micro-/nanoscale with minimal recourse to toxic reactants and solvents. Another potential advantage is to obtain simultaneous sterilization when the absorbed doses are within the sterilization dose range. This short review will highlight opportunities and challenges of the radiation technologies to produce bio-hybrid nanogels as delivery devices of therapeutic biomolecules to the target cells, tissues, and organs, and to create hydrogel patterns at the nano-length and micro-length scales on surfaces.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Keyword
- radiation chemistry
- micro-
- nano-gel patterns
- nanogels
- bio-hybrid hydrogels
- drug delivery
- tissue engineering
Publication and Content Type
- ref (subject category)
- for (subject category)
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