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A microneedle platform for buccal macromolecule delivery

Caffarel-Salvador, Ester (author)
MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Kim, Soyoung (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Soares, Vance (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
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Tian, Ryan Yu (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Stern, Sarah R. (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Minahan, Daniel (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Yona, Raissa (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Lu, Xiaoya (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Zakaria, Fauziah R. (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.
Collins, Joy (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.
Wainer, Jacob (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Fractyl Labs Inc, 17 Hartwell Ave, Lexington, MA 02421 USA.
Wong, Jessica (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
McManus, Rebecca (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Tamang, Siddartha (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
McDonnell, Shane (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Ishida, Keiko (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Hayward, Alison (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.;MIT, Div Comparat Med, Cambridge, MA 02139 USA.
Liu, Xiewen (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Univ Oxford, Dept Mat, Parks Rd, Oxford OX1 3PH, England.
Hubalek, Frantisek (author)
Novo Nordisk AS, Global Res Technol Global Drug Discovery & Device, Malov, Denmark.
Fels, Johannes (author)
Novo Nordisk AS, Global Res Technol Global Drug Discovery & Device, Malov, Denmark.
Vegge, Andreas (author)
Novo Nordisk AS, Global Res Technol Global Drug Discovery & Device, Malov, Denmark.
Frederiksen, Morten Revsgaard (author)
Novo Nordisk AS, Global Res Technol Global Drug Discovery & Device, Malov, Denmark.
Rahbek, Ulrik (author)
Novo Nordisk AS, Global Res Technol Global Drug Discovery & Device, Malov, Denmark.
Yoshitake, Tadayuki (author)
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.;MIT, Res Lab Elect, Cambridge, MA 02139 USA.
Fujimoto, James (author)
MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA.;MIT, Res Lab Elect, Cambridge, MA 02139 USA.
Roxhed, Niclas (author)
KTH,Mikro- och nanosystemteknik,MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
Langer, Robert (author)
MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA.;MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
Traverso, Giovanni (author)
MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.;Harvard Med Sch, Brigham & Womens Hosp, Div Gastroenterol, Boston, MA 02115 USA.;MIT, Dept Mech Engn, Cambridge, MA 02139 USA.
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MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA;MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. MIT, Dept Chem Engn, Cambridge, MA 02139 USA.;MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA. (creator_code:org_t)
American Association for the Advancement of Science (AAAS), 2021
2021
English.
In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 7:4
Related links:
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially for the pediatric and elderly populations.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

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