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Clinicopathological...
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Montero, Angeles M.
(author)
Clinicopathological significance of the expression of PD-L1 in Non-Small Cell Lung Cancer
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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Elsevier BV,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-291350
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291350URI
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https://doi.org/10.1016/j.anndiagpath.2021.151701DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146275749URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20210310
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Introduction: PD1/PD-L1 pathway targeting therapies are nowadays an established treatment option for patients with NSCLC. We assessed whether PD-L1 expression in NSCLC tumor cells was associated with specific clinical features or overall survival using four different clones. Methods and results: A retrospective study included formalin-fixed paraffin embedded (FFPE) surgical tumors from 482 patients. PD-L1 status was assessed with immunohistochemistry in tumor cells on tissue microarrays using clones 28-8, 22C3, SP263 and SP142. Associations with OS were assessed by Kaplan-Meier and multivariate Cox's regression analysis. Patients' median age: 68 years (39–86); histology: adenocarcinoma (AdCa) 61%, squamous-cell carcinoma (SqCC) 33%, and large cell carcinoma (LCC) 6%; p-stage: IA (46%), IB (30%), IIA (10%), IIB (11,4%), IIIA (1,2%), IIIB – IV (0,4%). PD-L1 positivity (≥1%) in NSCLC for clones 28-8, 22C3, SP263, SP142 was 41.5%, 34.2%, 42.7%, 10.4%, respectively (Pearson Chi-square p < 0.0001). PD-L1 expression was correlated with histology, tumor size and grading. Statistically significant association between PD-L1 expression and OS in NSCLC and Non-AdCa was observed with clone SP142 (log-rank p = 0.045 and p = 0.05, respectively). Statistically significant association between PD-L1 expression and OS in LCC was observed with clones 22C3 (log-rank p = 0.009) and SP263 (log-rank p = 0.050). Conclusions: Overexpression of the PD-L1 clone SP142 was associated with poor overall survival in NSCLC and Non-AdCa. Clones 22C3 and SP263 were associated with poor prognosis in LCC. PD-L1 status might serve as a prognostic marker in NSCLC.
Subject headings and genre
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Lung cancer and immunotherapy
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Predictive biomarkers in no
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n-small cell lung cancer
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PD-L1 status in tumor cells
Added entries (persons, corporate bodies, meetings, titles ...)
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Ozan, Aricak
(author)
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Kis, Lorand
(author)
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Yoshikawa, Akira
(author)
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De Petris, LuigiKarolinska Institutet
(author)
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Grundberg, OscarKarolinska Institutet
(author)
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Pham, Hoa H. N.
(author)
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Roden, Anja C
(author)
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Fukuoka, Junya
(author)
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Attanoos, Richard
(author)
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Guijarro, Ricardo
(author)
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Alarcón, Feliz
(author)
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Lindström, Kati,1977-KTH,Historiska studier av teknik, vetenskap och miljö(Swepub:kth)u171b46t
(author)
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Ortiz-Villalón, CristianKarolinska Institutet
(author)
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Karolinska InstitutetHistoriska studier av teknik, vetenskap och miljö
(creator_code:org_t)
Related titles
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In:Annals of Diagnostic Pathology: Elsevier BV51, s. 151701-1092-91341532-8198
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Montero, Angeles ...
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Ozan, Aricak
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Kis, Lorand
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Yoshikawa, Akira
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De Petris, Luigi
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Grundberg, Oscar
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Pham, Hoa H. N.
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Roden, Anja C
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Fukuoka, Junya
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Attanoos, Richar ...
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Guijarro, Ricard ...
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Alarcón, Feliz
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Lindström, Kati, ...
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Ortiz-Villalón, ...
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Annals of Diagno ...
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Royal Institute of Technology
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Karolinska Institutet