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  • Huang, JinrongLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China.;Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.;Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark. (författare)

A porcine brain-wide RNA editing landscape

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-06-10
  • Springer Nature,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-298865
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298865URI
  • https://doi.org/10.1038/s42003-021-02238-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146890521URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20210720
  • Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is an essential post-transcriptional modification. Although hundreds of thousands of RNA editing sites have been reported in mammals, brain-wide analysis of the RNA editing in the mammalian brain remains rare. Here, a genome-wide RNA-editing investigation is performed in 119 samples, representing 30 anatomically defined subregions in the pig brain. We identify a total of 682,037 A-to-I RNA editing sites of which 97% are not identified before. Within the pig brain, cerebellum and olfactory bulb are regions with most edited transcripts. The editing level of sites residing in protein-coding regions are similar across brain regions, whereas region-distinct editing is observed in repetitive sequences. Highly edited conserved recoding events in pig and human brain are found in neurotransmitter receptors, demonstrating the evolutionary importance of RNA editing in neurotransmission functions. Although potential data biases caused by age, sex or health status are not considered, this study provides a rich resource to better understand the evolutionary importance of post-transcriptional RNA editing. Huang et al performed a genome-wide RNA editing investigation in the porcine brain in which they found over 680,000 A-to-I RNA editing sites. They identified conserved recoding events between pig and human brains thus providing an extensive resource to aid our understanding of the evolutionary importance of post-transcriptional RNA editing.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lin, LinAarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark. (författare)
  • Dong, ZhanyingLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China. (författare)
  • Yang, LingLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China. (författare)
  • Zheng, TianyuLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China. (författare)
  • Gu, WeiwangWuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China. (författare)
  • Zhang, YanWuhan Univ, Renmin Hosp, Dept Clin Lab, Wuhan, Hubei, Peoples R China. (författare)
  • Yin, TailangWuhan Univ, Renmin Hosp, Dept Clin Lab, Wuhan, Hubei, Peoples R China. (författare)
  • Sjöstedt, EvelinaKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.(Swepub:kth)u12iezpl (författare)
  • Mulder, JanKarolinska Institutet (författare)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.(Swepub:kth)u1dulvmw (författare)
  • Kristiansen, Karsten (författare)
  • Bolund, LarsLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark. (författare)
  • Luo, YonglunLars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China.;Aarhus Univ, Dept Biomed, Aarhus, Denmark. (författare)
  • Lars Bolund Inst Regenerat Med, Shenzhen, Peoples R China.;Qingdao Europe Adv Inst Life Sci, Qingdao, Peoples R China.;Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, Copenhagen, Denmark.;Aarhus Univ, Dept Biomed, Aarhus, Denmark.;Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark.Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Communications Biology: Springer Nature4:12399-3642

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