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  • Hussein, Mohamed Ahmed MohamadyUniv Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt. (author)

Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-300952
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-300952URI
  • https://doi.org/10.1016/j.carbpol.2021.118373DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20210903
  • Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.

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  • Guler, EceMarmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey. (author)
  • Rayaman, ErkanMarmara Univ, Dept Pharmaceut Microbiol, Istanbul, Turkey. (author)
  • Cam, Muhammet EminMarmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey.;UCL, Dept Mech Engn, Torrington Pl, London W E 7JE, England. (author)
  • Sahin, AliMarmara Univ, Sch Med, Dept Biochem, Genet & Metab Dis Res & Invest Ctr, TR-34722 Istanbul, Turkey. (author)
  • Grinholc, MariuszUniv Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, Lab Mol Diagnost, Gdansk, Poland. (author)
  • Mansuroglu, Demet SezginIstanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey. (author)
  • Sahin, Yesim MugeIstanbul Arel Univ, Polymer Technol & Composite Applicat & Res Ctr Ar, TR-34537 Istanbul, Turkey. (author)
  • Gunduz, OguzhanMarmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey. (author)
  • Muhammed, MamounKTH(Swepub:kth)u1m5r8td (author)
  • El-Sherbiny, Ibrahim M.Zewail City Sci & Technol, Ctr Mat Sci CMS, Nanomed Lab, Giza 12578, Egypt. (author)
  • Megahed, MosaadUniv Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany. (author)
  • Univ Hosp RWTH Aachen, Dermatol Clin, D-52074 Aachen, Germany.;Natl Res Ctr, Div Med Res, Dept Pharmacol, Cairo 12622, Egypt.Marmara Univ, Ctr Nanotechnol & Biomat Applicat & Res NBUAM, TR-34722 Istanbul, Turkey.;Marmara Univ, Dept Pharmacol, Fac Pharm, TR-34716 Istanbul, Turkey. (creator_code:org_t)

Related titles

  • In:Carbohydrate Polymers: Elsevier BV2700144-86171879-1344

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