Sökning: WFRF:(Saqr Mohammed)
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Utility of SPECT Fu...
Utility of SPECT Functional Neuroimaging of Pain
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- Bermo, Mohammed (författare)
- Virginia Tech Carilion Sch Med, Roanoke, VA 24016 USA.
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- Abdelgalil, Mohammed Saqr (författare)
- KTH,Medieteknik och interaktionsdesign, MID,Univ Eastern Finland, Sch Comp, Joensuu Campus, Joensuu, Finland.
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- Hoffman, Hunter (författare)
- Univ Washington, Seattle, WA 98195 USA.
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- Patterson, David (författare)
- Univ Washington, Seattle, WA 98195 USA.
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- Sharar, Sam (författare)
- Univ Washington, Seattle, WA 98195 USA.
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- Minoshima, Satoshi (författare)
- Univ Utah, Salt Lake City, UT USA.
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- Lewis, David H. (författare)
- Univ Washington, Seattle, WA 98195 USA.
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Virginia Tech Carilion Sch Med, Roanoke, VA 24016 USA Medieteknik och interaktionsdesign, MID (creator_code:org_t)
- 2021-07-29
- 2021
- Engelska.
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Ingår i: Frontiers in Psychiatry. - : Frontiers Media SA. - 1664-0640. ; 12
- Relaterad länk:
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https://doi.org/10.3...
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Functional neuroimaging modalities vary in spatial and temporal resolution. One major limitation of most functional neuroimaging modalities is that only neural activation taking place inside the scanner can be imaged. This limitation makes functional neuroimaging in many clinical scenarios extremely difficult or impossible. The most commonly used radiopharmaceutical in Single Photon Emission Tomography (SPECT) functional brain imaging is Technetium 99 m-labeled Ethyl Cysteinate Dimer (ECD). ECD is a lipophilic compound with unique pharmacodynamics. It crosses the blood brain barrier and has high first pass extraction by the neurons proportional to regional brain perfusion at the time of injection. It reaches peak activity in the brain 1 min after injection and is then slowly cleared from the brain following a biexponential mode. This allows for a practical imaging window of 1 or 2 h after injection. In other words, it freezes a snapshot of brain perfusion at the time of injection that is kept and can be imaged later. This unique feature allows for designing functional brain imaging studies that do not require the patient to be inside the scanner at the time of brain activation. Functional brain imaging during severe burn wound care is an example that has been extensively studied using this technique. Not only does SPECT allow for imaging of brain activity under extreme pain conditions in clinical settings, but it also allows for imaging of brain activity modulation in response to analgesic maneuvers whether pharmacologic or non-traditional such as using virtual reality analgesia. Together with its utility in extreme situations, SPECTS is also helpful in investigating brain activation under typical pain conditions such as experimental controlled pain and chronic pain syndromes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- SPECT
- pain
- ECD
- brain
- functional imaging
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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