SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Langin Dominique)
 

Search: WFRF:(Langin Dominique) > The long noncoding ...

  • Alastair, Kerrkarolinska institutet (author)

The long noncoding RNA ADIPINT is a gatekeeper of pyruvate carboxylasefunction regulating human fat cell metabolism

  • BookEnglish

Publisher, publication year, extent ...

  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-304510
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-304510URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

Notes

  • QC 20211108
  • The pleiotropic function of long noncoding RNAs (lncRNAs) is well recognized,but their direct role in governingmetabolic homeostasis is less understood. Herein,we describe a human adipocyte-specific lncRNA, ADIPINT, that regulatespyruvate carboxylase (PC) an enzyme pivotal to energy metabolism. With a novelapproach, Targeted RNA-protein identification using Orthogonal Organic PhaseSeparation (TROOPS) and validation with electron microscopy, we show thatADIPINT binds to PC. ADIPINT knockdown alters the interactome anddecreases the mitochondrial abundance and enzymatic activty of PC. Decreases inADIPINT or PC expression reduce adipocyte lipid synthesis, breakdown and lipidcontent. In human white adipose tissue, ADIPINT expression is increased inobesity, linked to fat cell size, adipose insulin resistance and PC activity. Thus, weidentify ADIPINT as a regulator of lipid metabolism in human white adipocytes,which at least in part is mediated through its interaction with PC.

Subject headings and genre

  • long noncoding RNAs
  • pyruvate carboxylase
  • Bioteknologi
  • Biotechnology

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wang, Zuoneng,1991-KTH,Skolan för kemi, bioteknologi och hälsa (CBH),Carsten Mim(Swepub:kth)u1jskro6 (author)
  • Na, Wangkarolinska institutet (author)
  • Kwok, Kelvinkarolinska institutet (author)
  • Jalkanen, Juttakarolinska institutet (author)
  • Ludzki, Alisonkarolinska institutet (author)
  • Langin, Dominique (author)
  • Bergö, Martinkarolinska institutet (author)
  • Dahlman, Ingridkarolinska institutet (author)
  • Mim, CarstenKTH,Strukturell bioteknik(Swepub:kth)u1ce0qjf (author)
  • Arner, Peterkarolinska institutet (author)
  • Gao, Huikarolinska institutet (author)
  • karolinska institutetSkolan för kemi, bioteknologi och hälsa (CBH) (creator_code:org_t)

Internet link

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view