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The spatial landsca...
The spatial landscape of transcriptomes and genomes in pediatric brain tumors
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- Kvastad, Linda (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Mirzazadeh, Reza (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Larsson, Ludvig (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Mollbrink, Annelie (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Shamikh, Alia (author)
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
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- Basmaci, Elisa (author)
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
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- Prochazka, Gabriela (author)
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
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- Diaz De Ståhl, Teresita (author)
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
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- Erickson, Andrew (author)
- Nuffield Department of Surgical Sciences, University of Oxford, UK.
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- Lamb, Alastair D (author)
- Nuffield Department of Surgical Sciences, University of Oxford, UK. Department of Urology, Oxford University Hospitals NHS Foundation Trust, UK.
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- Nistér, Monica (author)
- Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden. Department of Clinical Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- Treatment of pediatric brain tumors is continually being improved; still, there is a great need for new treatment options. Here we explore the spatial transcriptomic and genomic landscape in a cohort of pediatric brain tumors using a new generation of unbiased methodologies. We demonstrate the gene expression patterns of the essential cancer-related gene programs of epithelial-to-mesenchymal transition (EMT), the reverse process mesenchymal-to-epithelial transition (MET), and tumor microenvironment (TME) observations through microglia. Furthermore, we identify the gene expression of SPP1 by microglia in the TME as a potential prognostic mRNA marker - in pediatric brain tumor relapse patients.
Keyword
- Bioteknologi
- Biotechnology
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Kvastad, Linda
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Mirzazadeh, Reza
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Larsson, Ludvig
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Mollbrink, Annel ...
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Shamikh, Alia
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Basmaci, Elisa
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show more...
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Prochazka, Gabri ...
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Diaz De Ståhl, T ...
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Erickson, Andrew
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Lamb, Alastair D
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Nistér, Monica
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Lundeberg, Joaki ...
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- By the university
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Royal Institute of Technology