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Sökning: id:"swepub:oai:DiVA.org:kth-305641" > Identification of E...

  • Iglesias, Maria JesusKTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Univ Hosp North Norway, Div Internal Med, Tromso, Norway. (författare)

Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • Ovid Technologies (Wolters Kluwer Health),2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-305641
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305641URI
  • https://doi.org/10.1161/ATVBAHA.121.316779DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:148200627URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20211206
  • Objective: Endothelial cell (EC) dysfunction is a well-established response to cardiovascular disease risk factors, such as smoking and obesity. Risk factor exposure can modify EC signaling and behavior, leading to arterial and venous disease development. Here, we aimed to identify biomarker panels for the assessment of EC dysfunction, which could be useful for risk stratification or to monitor treatment response. Approach and Results: We used affinity proteomics to identify EC proteins circulating in plasma that were associated with cardiovascular disease risk factor exposure. Two hundred sixteen proteins, which we previously predicted to be EC-enriched across vascular beds, were measured in plasma samples (N=1005) from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study) pilot. Thirty-eight of these proteins were associated with body mass index, total cholesterol, low-density lipoprotein, smoking, hypertension, or diabetes. Sex-specific analysis revealed that associations predominantly observed in female- or male-only samples were most frequently with the risk factors body mass index, or total cholesterol and smoking, respectively. We show a relationship between individual cardiovascular disease risk, calculated with the Framingham risk score, and the corresponding biomarker profiles. Conclusions: EC proteins in plasma could reflect vascular health status.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kruse, Larissa D.KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab(Swepub:kth)PI000000 (författare)
  • Sanchez-Rivera, LauraKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u13bwsp9 (författare)
  • Enge, LinneaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab(Swepub:kth)PI000000 (författare)
  • Dusart, PhilipKTH,Cellulär och klinisk proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u13mq3yk (författare)
  • Hong, Mun-GwanKTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap(Swepub:kth)u19gmsru (författare)
  • Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1dulvmw (författare)
  • Renne, ThomasUniv Med Ctr Hamburg Eppendorf, Inst Clin Chem & Lab Med, Hamburg, Germany.;Royal Coll Surgeons Ireland, Irish Ctr Vasc Biol, Sch Pharm & Biomol Sci, Dublin, Ireland.;Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis CTH, Med Ctr, Mainz, Germany. (författare)
  • Schwenk, Jochen M.KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik(Swepub:kth)u1h7wtme (författare)
  • Bergstrom, GoranUniv Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden. (författare)
  • Odeberg, Jacob,Professor,1963-KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap,Univ Hosp North Norway, Div Internal Med, Tromso, Norway.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Karolinska Univ Hosp, Dept Hematol, Coagulat Unit, Stockholm, Sweden.(Swepub:kth)u1e4yljo (författare)
  • Butler, Lynn M.Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Karolinska Inst, Dept Mol Med & Surg, Clin Chem & Blood Coagulat Res, SE-17176 Stockholm, Sweden.;Arctic Univ Norway, Dept Clin Med, Tromso, Norway.;Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, Stockholm, Sweden.(Swepub:kth)u1tkjrxa (författare)
  • KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Arteriosclerosis, Thrombosis and Vascular Biology: Ovid Technologies (Wolters Kluwer Health)41:12, s. 2990-30041079-56421524-4636

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