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Evidence of diffuse...
Evidence of diffuse cerebellar neuroinflammation in multiple sclerosis by 11C-PBR28 MR-PET
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Barletta, VT (författare)
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Herranz, E (författare)
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Treaba, CA (författare)
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- Ouellette, R (författare)
- Karolinska Institutet
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Mehndiratta, A (författare)
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Loggia, ML (författare)
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Klawiter, EC (författare)
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Ionete, C (författare)
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Jacob, SA (författare)
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Mainero, C (författare)
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(creator_code:org_t)
- 2019-04-11
- 2020
- Engelska.
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Ingår i: Multiple sclerosis (Houndmills, Basingstoke, England). - : SAGE Publications. - 1477-0970 .- 1352-4585. ; 26:6, s. 668-678
- Relaterad länk:
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https://journals.sag...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Activated microglia, which can be detected in vivo by 11C-PBR28 positron emission tomography (PET), represent a main component of MS pathology in the brain. Their role in the cerebellum is still unexplored, although cerebellar involvement in MS is frequent and accounts for disability progression. Objectives: We aimed at characterizing cerebellar neuroinflammation in MS patients compared to healthy subjects by combining 11C-PBR28 MRI-Positron Emission Tomography (MR-PET) with 7 Tesla (T) MRI and assessing its relationship with brain neuroinflammation and clinical outcome measures. Methods: Twenty-eight MS patients and 16 healthy controls underwent 11C-PBR28 MR-PET to measure microglia activation in normal appearing cerebellum and lesions segmented from 7 T scans. Patients were evaluated using the Expanded Disability Status Scale and Symbol Digit Modalities Test. 11C-PBR28 binding was assessed in regions of interest using 60–90 minutes standardized uptake values normalized by a pseudo-reference region in the brain normal appearing white matter. Multilinear regression was used to compare tracer uptake in MS and healthy controls and assess correlations with clinical scores. Results: In all cerebellar regions examined, MS patients showed abnormally increased tracer uptake, which correlated with cognitive and neurological disability. Conclusion: Neuroinflammation is widespread in the cerebellum of patients with MS and related to neurological disability and cognitive impairment.
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Till lärosätets databas
- Av författaren/redakt...
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Barletta, VT
-
Herranz, E
-
Treaba, CA
-
Ouellette, R
-
Mehndiratta, A
-
Loggia, ML
-
visa fler...
-
Klawiter, EC
-
Ionete, C
-
Jacob, SA
-
Mainero, C
-
visa färre...
- Artiklar i publikationen
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Multiple scleros ...
- Av lärosätet
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Karolinska Institutet