Dendritic Hydrogels Induce Immune Modulation in Human Keratinocytes and Effectively Eradicate Bacterial Pathogens

QC 20211206
Infections caused by antibiotic-resistant bacteria are globally a major threat, leading to high mortality rates and increased economic burden. Novel treatment strategies are therefore urgently needed by healthcare providers to protect people. Biomaterials that have inherent antibacterial properties and do not require the use of antibiotics present an attractive and feasible avenue to achieve this goal. Herein, we demonstrate the effect of a new class of cationic hydrogels based on amino-functional hyperbranched dendritic-linear-dendritic copolymers (HBDLDs) exhibiting excellent antimicrobial activity toward a wide range of clinical Gram-positive and Gram-negative bacteria, including drug-resistant strains isolated from wounds. Intriguingly, the hydrogels can induce the expression of the antimicrobial peptides RNase 7 and psoriasin, promoting host-mediated bacterial killing in human keratinocytes (HaCaT). Moreover, treatment with the hydrogels decreased the proinflammatory cytokine IL-1 beta, reactive nitrogen species (NO), and mitochondrial reactive oxygen species (ROS) in S. aureus-infected HaCaT cells, conjunctively resulting in reduced inflammation.

Mohanty, SoumitraKarolinska Institutet (författare)
Zhang, YuningKTH,Ytbehandlingsteknik(Swepub:kth)u1bh78yi (författare)
Lüchow, MadsKTH,Fiber- och polymerteknologi(Swepub:kth)u1x2ksfd (författare)
Qin, LiguoKTH,Fiber- och polymerteknologi,Xi An Jiao Tong Univ, Inst Design Sci & Basic Components, Xian 710049, Peoples R China.(Swepub:kth)u1qdnq3n (författare)
Fortuin, LisaKTH,Fiber- och polymerteknologi(Swepub:kth)u1l5i7al (författare)
Brauner, AnnelieKarolinska Institutet (författare)
Malkoch, Michael,1974-KTH,Ytbehandlingsteknik(Swepub:kth)u18z6ljf (författare)
KTHYtbehandlingsteknik (creator_code:org_t)

Ingår i:Journal of the American Chemical Society: American Chemical Society (ACS)143:41, s. 17180-171900002-78631520-5126

Av författaren/redakt...: Fan, Yanmiao; Mohanty, Soumitr ...; Zhang, Yuning; Lüchow, Mads; Qin, Liguo; Fortuin, Lisa; visa fler...; Brauner, Annelie; Malkoch, Michael ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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