Sökning: WFRF:(Heyes Derren) >
Isolation and chara...
Isolation and characterisation of 13 pterosins and pterosides from bracken (Pteridium aquilinum (L.) Kuhn) rhizome
-
- Mohammad, Rizgar Hassan (författare)
- Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
-
- Nur-e-Alam, Mohammad (författare)
- Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.;King Saud Univ, Dept Pharmacognosy, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia.
-
- Lahmann, Martina (författare)
- Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
-
visa fler...
-
- Parveen, Ifat (författare)
- Aberystwyth Univ, IBERS, Aberystwyth SY23 3DA, Dyfed, Wales.
-
- Tizzard, Graham J. (författare)
- Univ Southampton, Sch Chem, UK Natl Crystallog Serv, Univ Rd, Southampton SO17 1BJ, Hants, England.
-
- Coles, Simon J. (författare)
- Univ Southampton, Sch Chem, UK Natl Crystallog Serv, Univ Rd, Southampton SO17 1BJ, Hants, England.
-
- Fowler, Mark (författare)
- Unilever R&D, Strateg Sci Grp, Colworth Sci Pk, Bedford MK44 1LQ, England.
-
- Drake, Alex F. (författare)
- Kings Coll London, Pharmaceut Opt & Chiropt Spect Facil, Biomol Spect Ctr, Wolfson Wing,WWB10 Hodgkin Bldg,Guys Campus, London SE1 1UL, England.
-
- Heyes, Derren (författare)
- Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England.
-
- Thoss, Vera (författare)
- Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.
-
visa färre...
-
Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales Bangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.;King Saud Univ, Dept Pharmacognosy, Coll Pharm, POB 2457, Riyadh 11451, Saudi Arabia. (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
-
Ingår i: Phytochemistry. - : Elsevier BV. - 0031-9422 .- 1873-3700. ; 128, s. 82-94
- Relaterad länk:
-
https://eprints.soto...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Systematic phytochemical investigations of the underground rhizome of Pteridium aquilinum (L.) Kuhn (Dennstaedtiaceae) afforded thirty-five pterosins and pterosides. By detailed analysis of one- and two-dimensional nuclear magnetic resonance spectroscopy, circular dichroism (CD) and high-resolution mass spectrometric data, thirteen previously undescribed pterosins and pterosides have been identified. Interestingly, for the first time 12-O-beta-D-glucopyranoside substituted pterosins, rhedynosides C and D, and the sulfate-containing pterosin, rhedynosin H, alongside the two known compounds, histiopterosin A and (2S)-pteroside A2, were isolated from the rhizomes of subsp. aquilinum of bracken. In addition, six-membered cyclic ether pterosins and pterosides, rhedynosin A and rhedynoside A, are the first examples of this type of pterosin-sesquiterpenoid. Additionally, the three previously reported compounds (rhedynosin I, (2S)-2-hydroxymethylpterosin E and (2S)-12-hydroxypterosin A) were obtained for the first time from plants as opposed to mammalian metabolic products. Single crystal X-ray diffraction analysis was applied to the previously undescribed compounds (2R)-rhedynoside B, (2R)pteroside B and (2S)-pteroside K, yielding the first crystal structures for pterosides, and three known pterosins, (2S)-pterosin A, trans-pterosin C and cis-pterosin C. Rhedynosin C is the only example of the cyclic lactone pterosins with a keto group at position C-14. Six selected pterosins ((2S)-pterosin A, (2R)pterosin B and trans-pterosin C) and associated glycosides ((2S)-pteroside A, (2R)-pteroside B and pterbside Z) were assessed for their anti -diabetic activity using an intestinal glucose uptake assay; all were found to be inactive at 300 mu M.
Ämnesord
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Pteridium aquilinum
- Dennstaedtiaceae
- Bracken pterosins
- Pterosides
- Norsesquiterpenes
- Sesquiterpenoids
- Pterosins A and B
- Circular dichroism
- SGLT1 and GLUT2 transporters
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mohammad, Rizgar ...
-
Nur-e-Alam, Moha ...
-
Lahmann, Martina
-
Parveen, Ifat
-
Tizzard, Graham ...
-
Coles, Simon J.
-
visa fler...
-
Fowler, Mark
-
Drake, Alex F.
-
Heyes, Derren
-
Thoss, Vera
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Kemi
-
och Fysikalisk kemi
- Artiklar i publikationen
-
Phytochemistry
- Av lärosätet
-
Kungliga Tekniska Högskolan