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Multivalent glycoco...
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Bernardi, AnnaUniv Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy.;Univ Milan, Ctr Eccellenza CISI, I-20133 Milan, Italy.
(author)
Multivalent glycoconjugates as anti-pathogenic agents
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013
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Royal Society of Chemistry (RSC),2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-305700
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-305700URI
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https://doi.org/10.1039/c2cs35408jDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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QC 20211206
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Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Jimenez-Barbero, JesusCSIC, Ctr Invest Biol, Madrid 28040, Spain.
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Casnati, AlessandroUniv Parma, Dipartimento Chim, I-43100 Parma, Italy.
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De Castro, CristinaUniv Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy.
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Darbre, TamisUniv Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland.
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Fieschi, FranckInst Biol Struct, F-38027 Grenoble 1, France.
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Finne, JukkaUniv Helsinki, Dept Biosci, FI-00014 Helsinki, Finland.
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Funken, HorstUniv Dusseldorf, Forschungszentrum Julich, Inst Mol Enzyme Technol, D-42425 Julich, Germany.
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Jaeger, Karl-ErichUniv Dusseldorf, Forschungszentrum Julich, Inst Mol Enzyme Technol, D-42425 Julich, Germany.
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Lahmann, MartinaBangor Univ, Sch Chem, Bangor LL57 2UW, Gwynedd, Wales.(Swepub:kth)u190mcjj
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Lindhorst, Thisbe K.Univ Kiel, Otto Diels Inst Organ Chem, D-24098 Kiel, Germany.
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Marradi, MarcoCIC BiomaGUNE, Lab GlycoNanotechnol, San Sebastian 20009, Spain.;CIBER BBN, San Sebastian 20009, Spain.
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Messner, PaulUniv Nat Resources & Life Sci, NanoGlycobiol Unit, Dept NanoBiotechnol, A-1190 Vienna, Austria.
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Molinaro, AntonioUniv Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy.
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Murphy, Paul V.Natl Univ Ireland, Sch Chem, Galway, Ireland.
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Nativi, CristinaUniv Florence, Dipartimento Chim, I-50019 Sesto Fiorentino, Italy.
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Oscarson, StefanUniv Coll Dublin, UCD Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland.
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Penades, SoledadCIC BiomaGUNE, Lab GlycoNanotechnol, San Sebastian 20009, Spain.;CIBER BBN, San Sebastian 20009, Spain.
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Peri, FrancescoUniv Milano Bicocca, I-20126 Milan, Italy.
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Pieters, Roland J.Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem & Chem Biol, NL-3508 TB Utrecht, Netherlands.
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Renaudet, OlivierUniv Grenoble 1, UMR CNRS 5250, Dept Chim Mol, F-38041 Grenoble, France.;Univ Grenoble 1, ICMG FR 2607, F-38041 Grenoble, France.
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Reymond, Jean-LouisUniv Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland.
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Richichi, BarbaraUniv Florence, Dipartimento Chim, I-50019 Sesto Fiorentino, Italy.
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Rojo, JavierUniv Seville, CSIC, Inst Invest Quim, Glycosyst Lab, Seville 41092, Spain.
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Sansone, FrancescoUniv Parma, Dipartimento Chim, I-43100 Parma, Italy.
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Schaeffer, ChristinaUniv Nat Resources & Life Sci, NanoGlycobiol Unit, Dept NanoBiotechnol, A-1190 Vienna, Austria.
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Turnbull, W. BruceUniv Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England.;Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England.
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Velasco-Torrijos, TrinidadNatl Univ Ireland, Dept Chem, Maynooth, Kildare, Ireland.
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Vidal, SebastienUniv Lyon 1, CNRS, Inst Chim & Biochim Mol & Supramol UMR 5246, F-69622 Villeurbanne, France.;Univ Namur FUNDP, Dept Chim, Chim Bioorgan Lab, B-5000 Namur, Belgium.
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Vincent, Stephane
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Wennekes, TomWageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands.
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Zuilhof, HanWageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands.;King Abdulaziz Univ, Dept Chem & Mat Engn, Jeddah 21413, Saudi Arabia.
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Imberty, AnneUniv Grenoble, Ctr Rech Macromol Vegetales CERMAV CNRS, F-38041 Grenoble, France.
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Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy.;Univ Milan, Ctr Eccellenza CISI, I-20133 Milan, Italy.CSIC, Ctr Invest Biol, Madrid 28040, Spain.
(creator_code:org_t)
Related titles
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In:Chemical Society Reviews: Royal Society of Chemistry (RSC)42:11, s. 4709-47270306-00121460-4744
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Bernardi, Anna
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Jimenez-Barbero, ...
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Casnati, Alessan ...
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De Castro, Crist ...
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Darbre, Tamis
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Fieschi, Franck
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Finne, Jukka
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Funken, Horst
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Jaeger, Karl-Eri ...
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Lahmann, Martina
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Lindhorst, Thisb ...
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Marradi, Marco
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Messner, Paul
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Molinaro, Antoni ...
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Murphy, Paul V.
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Nativi, Cristina
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Oscarson, Stefan
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Penades, Soledad
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Peri, Francesco
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Pieters, Roland ...
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Renaudet, Olivie ...
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Reymond, Jean-Lo ...
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Richichi, Barbar ...
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Rojo, Javier
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Sansone, Frances ...
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Schaeffer, Chris ...
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Turnbull, W. Bru ...
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Velasco-Torrijos ...
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Vidal, Sebastien
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Vincent, Stephan ...
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Wennekes, Tom
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Zuilhof, Han
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Imberty, Anne
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