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A panel of CSF prot...
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Bergström, SofiaKTH,Affinitets-proteomik
(författare)
A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers : a GENFI study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-11-27
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Springer Nature,2021
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:kth-306381
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-306381URI
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https://doi.org/10.1186/s13024-021-00499-4DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148262897URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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QC 20211217
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Background A detailed understanding of the pathological processes involved in genetic frontotemporal dementia is critical in order to provide the patients with an optimal future treatment. Protein levels in CSF have the potential to reflect different pathophysiological processes in the brain. We aimed to identify and evaluate panels of CSF proteins with potential to separate symptomatic individuals from individuals without clinical symptoms (unaffected), as well as presymptomatic individuals from mutation non-carriers. Methods A multiplexed antibody-based suspension bead array was used to analyse levels of 111 proteins in CSF samples from 221 individuals from families with genetic frontotemporal dementia. The data was explored using LASSO and Random forest. Results When comparing affected individuals with unaffected individuals, 14 proteins were identified as potentially important for the separation. Among these, four were identified as most important, namely neurofilament medium polypeptide (NEFM), neuronal pentraxin 2 (NPTX2), neurosecretory protein VGF (VGF) and aquaporin 4 (AQP4). The combined profile of these four proteins successfully separated the two groups, with higher levels of NEFM and AQP4 and lower levels of NPTX2 in affected compared to unaffected individuals. VGF contributed to the models, but the levels were not significantly lower in affected individuals. Next, when comparing presymptomatic GRN and C9orf72 mutation carriers in proximity to symptom onset with mutation non-carriers, six proteins were identified with a potential to contribute to a separation, including progranulin (GRN). Conclusion In conclusion, we have identified several proteins with the combined potential to separate affected individuals from unaffected individuals, as well as proteins with potential to contribute to the separation between presymptomatic individuals and mutation non-carriers. Further studies are needed to continue the investigation of these proteins and their potential association to the pathophysiological mechanisms in genetic FTD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Oijerstedt, LinnKarolinska Institutet
(författare)
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Remnestål, JuliaKTH,Affinitets-proteomik(Swepub:kth)u13wztpi
(författare)
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Olofsson, JennieKTH,Affinitets-proteomik(Swepub:kth)u1q8hz5k
(författare)
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Ullgren, AbbeKarolinska Institutet
(författare)
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Seelaar, HarroErasmus MC, Dept Neurol, Rotterdam, Netherlands.
(författare)
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van Swieten, John C.Erasmus MC, Dept Neurol, Rotterdam, Netherlands.
(författare)
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Synofzik, MatthisUniv Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, Tubingen, Germany.;Univ Tubingen, Ctr Neurol, Tubingen, Germany.;Ctr Neurodegenerat Dis DZNE, Tubingen, Germany.
(författare)
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Sanchez-Valle, RaquelUniv Barcelona, Inst Invest Biomed August Pi I Sunyer, Hosp Clin, Alzheimers Dis & Other Cognit Disorders Unit,Neur, Barcelona, Spain.
(författare)
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Moreno, FerminDonostia Univ Hosp, Dept Neurol, Cognit Disorders Unit, San Sebastian, Gipuzkoa, Spain.;Biodonostia Hlth Res Inst, Neurosci Area, San Sebastian, Gipuzkoa, Spain.
(författare)
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Finger, ElizabethUniv Western Ontario, Dept Clin Neurol Sci, London, ON, Canada.
(författare)
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Masellis, MarioUniv Toronto, Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada.
(författare)
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Tartaglia, CarmelaUniv Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.
(författare)
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Vandenberghe, RikKatholieke Univ Leuven, Lab Cognit Neurol, Dept Neurosci, Leuven, Belgium.;Univ Hosp Leuven, Neurol Serv, Leuven, Belgium.;Katholieke Univ Leuven, Leuven Brain Inst, Leuven, Belgium.
(författare)
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Laforce, RobertUniv Laval, CHU Quebec, Dept Sci Neurol, Clin Interdisciplinaire Mem, Quebec City, PQ, Canada.;Univ Laval, Fac Med, Quebec City, PQ, Canada.
(författare)
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Galimberti, DanielaFdn IRCCS Osped Policlin, Milan, Italy.;Univ Milan, Ctr Dino Ferrari, Milan, Italy.
(författare)
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Borroni, BarbaraUniv Brescia, Ctr Neurodegenerat Disorders, Dept Clin & Expt Sci, Brescia, Italy.
(författare)
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Butler, Chris R.Univ Oxford, Nuffield Dept Clin Neurosci, Med Sci Div, Oxford, England.;Imperial Coll London, Dept Brain Sci, London, England.
(författare)
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Gerhard, AlexanderUniv Manchester, Wolfson Mol Imaging Ctr, Div Neurosci & Expt Psychol, Manchester, Lancs, England.;Univ Duisburg Essen, Dept Geriatr Med, Duisburg, Germany.;Univ Duisburg Essen, Dept Nucl Med, Duisburg, Germany.
(författare)
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Ducharme, SimonMcGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, Montreal, PQ, Canada.;McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Montreal, PQ, Canada.
(författare)
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Rohrer, Jonathan D.UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, Queen Sq, London, England.
(författare)
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Manberg, AnnaUniv Toronto, Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada.
(författare)
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Graff, CarolineKarolinska Institutet
(författare)
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Nilsson, PeterKTH,Affinitets-proteomik(Swepub:kth)u1ws88sk
(författare)
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KTHAffinitets-proteomik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Neurodegeneration: Springer Nature16:11750-1326
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Bergström, Sofia
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Oijerstedt, Linn
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Remnestål, Julia
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Olofsson, Jennie
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Ullgren, Abbe
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Seelaar, Harro
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visa fler...
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van Swieten, Joh ...
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Synofzik, Matthi ...
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Sanchez-Valle, R ...
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Moreno, Fermin
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Finger, Elizabet ...
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Masellis, Mario
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Tartaglia, Carme ...
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Vandenberghe, Ri ...
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Laforce, Robert
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Galimberti, Dani ...
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Borroni, Barbara
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Butler, Chris R.
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Gerhard, Alexand ...
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Ducharme, Simon
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Rohrer, Jonathan ...
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Manberg, Anna
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Graff, Caroline
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Nilsson, Peter
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