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Sökning: onr:"swepub:oai:DiVA.org:kth-306416" > Lysine demethylase ...

  • Zhao, Li-JuanCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)

Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-05-31
  • EMBO,2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-306416
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-306416URI
  • https://doi.org/10.15252/embr.202050922DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20211216
  • Several studies have examined the functions of nucleic acids in small extracellular vesicles (sEVs). However, much less is known about the protein cargos of sEVs and their functions in recipient cells. This study demonstrates the presence of lysine-specific demethylase 1 (LSD1), which is the first identified histone demethylase, in the culture medium of gastric cancer cells. We show that sEVs derived from gastric cancer cells and the plasma of patients with gastric cancer harbor LSD1. The shuttling of LSD1-containing sEVs from donor cells to recipient gastric cancer cells promotes cancer cell stemness by positively regulating the expression of Nanog, OCT4, SOX2, and CD44. Additionally, sEV-delivered LSD1 suppresses oxaliplatin response of recipient cells in vitro and in vivo, whereas LSD1-depleted sEVs do not. Taken together, we demonstrate that LSD1-loaded sEVs can promote stemness and chemoresistance to oxaliplatin. These findings suggest that the LSD1 content of sEV could serve as a biomarker to predict oxaliplatin response in gastric cancer patients.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Li, Ying-YingCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Zhang, Yu-TongCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Fan, Qi-QiCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Ren, Hong-MeiCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Zhang, ChengKTH,Science for Life Laboratory, SciLifeLab,Systembiologi(Swepub:kth)u1ww5kvp (författare)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England.(Swepub:kth)u1t8kmr6 (författare)
  • Chen, Wen-ChaoZhengzhou Univ, Henan Prov Peoples Hosp, Dept Gastrointestinal Surg, Zhengzhou, Peoples R China. (författare)
  • Pang, Jing-RuCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Shen, Dan-DanCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Wang, Jun-WeiCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Zhao, Long-FeiCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Zhang, Jian-YingZhengzhou Univ, Henan Inst Med & Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Wang, Zhen-YaZhengzhou Univ, Inst Drug Discovery & Dev, Key Lab Runliang Antiviral Medicines Res & Dev, Zhengzhou, Peoples R China. (författare)
  • Zheng, Yi-ChaoCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Liu, Hong-MinCollaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China. (författare)
  • Collaborat Innovat Ctr New Drug Res & Safety Eval, State Key Lab Esophageal Canc Prevent & Treatment, Key Lab Adv Drug Preparat Technol, Minist Educ China, Zhengzhou, Henan, Peoples R China.;Zhengzhou Univ, Acad Med Sci, Key Lab Henan Prov Drug Qual & Evaluat, Inst Drug Discovery & Dev,Sch Pharmaceut Sci, Zhengzhou, Peoples R China.Science for Life Laboratory, SciLifeLab (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:EMBO Reports: EMBO22:81469-221X1469-3178

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