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SATB1, genomic instability and Gleason grading constitute a novel risk score for prostate cancer

Dumke, Christoph (author)
Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.
Gemoll, Timo (author)
Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.
Oberlaender, Martina (author)
Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Lubeck, Interdisciplinary Ctr Biobanking Lubeck ICBL, Lubeck, Germany.
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Freitag-Wolf, Sandra (author)
Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Campus Kiel, Kiel, Germany.
Thorns, Christoph (author)
Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Lubeck, Inst Pathol, Campus Lubeck, Lubeck, Germany.
Glaessgen, Axel (author)
Unilabs AB, Dept Clin Pathol & Cytol, Stockholm, Sweden.
Klooster, Rinse (author)
Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands.
van der Maarel, Silvere M. (author)
Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands.
Widengren, Jerker (author)
KTH,Kvant- och biofotonik
Doehn, Christian (author)
Urologikum Lubeck, Lubeck, Germany.
Auer, Gert (author)
Karolinska Institutet
Habermann, Jens K. (author)
Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Lubeck, Interdisciplinary Ctr Biobanking Lubeck ICBL, Lubeck, Germany.;Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany. Univ Lubeck, Sect Translat Surg Oncol & Biobanking, Dept Surg, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Hosp Schleswig Holstein, Campus Lubeck,Ratzeburger Allee 160, D-23538 Lubeck, Germany.;Univ Lubeck, Interdisciplinary Ctr Biobanking Lubeck ICBL, Lubeck, Germany. (creator_code:org_t)
2021-12-27
2021
English.
In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 11:1
Related links:
https://doi.org/10.1...
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https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Current prostate cancer risk classifications rely on clinicopathological parameters resulting in uncertainties for prognostication. To improve individual risk stratification, we examined the predictive value of selected proteins with respect to tumor heterogeneity and genomic instability. We assessed the degree of genomic instability in 50 radical prostatectomy specimens by DNA-Image-Cytometry and evaluated protein expression in related 199 tissue-microarray (TMA) cores. Immunohistochemical data of SATB1, SPIN1, TPM4, VIME and TBB5 were correlated with the degree of genomic instability, established clinical risk factors and overall survival. Genomic instability was associated with a GS >= 7 (p = 0.001) and worse overall survival (p = 0.008). A positive SATB1 expression was associated with a GS <= 6 (p = 0.040), genomic stability (p = 0.027), and was a predictor for increased overall survival (p = 0.023). High expression of SPIN1 was also associated with longer overall survival (p = 0.048) and lower preoperative PSA-values (p = 0.047). The combination of SATB1 expression, genomic instability, and GS lead to a novel Prostate Cancer Prediction Score (PCP-Score) which outperforms the current D'Amico et al. stratification for predicting overall survival. Low SATB1 expression, genomic instability and GS >= 7 were identified as markers for poor prognosis. Their combination overcomes current clinical risk stratification regimes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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