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  • Juanes-Velasco, PabloUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)

Deciphering Biomarkers for Leptomeningeal Metastasis in Malignant Hemopathies (Lymphoma/Leukemia) Patients by Comprehensive Multipronged Proteomics Characterization of Cerebrospinal Fluid

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-01-17
  • MDPI AG,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-308672
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-308672URI
  • https://doi.org/10.3390/cancers14020449DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20220215
  • Simple Summary The early diagnosis of leptomeningeal disease is a challenge because it is asymptomatic in the early stages. Consequently, it is important to identify a panel of biomarkers to help in its diagnosis and/or prognosis. For this purpose, we explored a multipronged proteomics approach in cerebrospinal fluid (CSF) to determine a potential panel of biomarkers. Thus, a systematic and exhaustive characterization of more than 300 CSF samples was performed by an integrated approach by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and functional proteomics analysis to establish protein profiles, which were useful for developing a panel of biomarkers validated by in silico approaches. In the present work, leptomeningeal disease, a very destructive form of systemic cancer, was characterized from several proteomics points of view. This pathology involves the invasion of the leptomeninges by malignant tumor cells. The tumor spreads to the central nervous system through the cerebrospinal fluid (CSF) and has a very grim prognosis; the average life expectancy of patients who suffer it does not exceed 3 months. The early diagnosis of leptomeningeal disease is a challenge because, in most of the cases, it is an asymptomatic pathology. When the symptoms are clear, the disease is already in the very advanced stages and life expectancy is low. Consequently, there is a pressing need to determine useful CSF proteins to help in the diagnosis and/or prognosis of this disease. For this purpose, a systematic and exhaustive proteomics characterization of CSF by multipronged proteomics approaches was performed to determine different protein profiles as potential biomarkers. Proteins such as PTPRC, SERPINC1, sCD44, sCD14, ANPEP, SPP1, FCGR1A, C9, sCD19, and sCD34, among others, and their functional analysis, reveals that most of them are linked to the pathology and are not detected on normal CSF. Finally, a panel of biomarkers was verified by a prediction model for leptomeningeal disease, showing new insights into the research for potential biomarkers that are easy to translate into the clinic for the diagnosis of this devastating disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Galicia, NormaUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1pmjyje (författare)
  • Jara-Acevedo, RicardoUniv Coimbra, Immunostep SL Inst Canc Res, Av Univ Coimbra, Salamanca 37007, Spain. (författare)
  • Carabias-Sanchez, JavierUniv Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Garcia-Valiente, RodrigoUniv Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Lecrevisse, QuentinUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Pedreira, Carlos EduardoUniv Fed Rio de Janeiro UFRJ, Syst & Comp Dept COPPE PESC, BR-21941914 Rio De Janeiro, Brazil. (författare)
  • Gongora, RafaelUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Sanchez-Santos, Jose ManuelUniv Salamanca, Stat Dept, Salamanca 37008, Spain. (författare)
  • Lorenzo-Gil, HectorUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Landeira-Vinuela, AliciaUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Bareke, HalinUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Orfao, AlbertoUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Nilsson, PeterKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1ws88sk (författare)
  • Fuentes, ManuelUniv Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (författare)
  • Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.Univ Salamanca, CSIC, Deparment Med, Canc Res Cent IBMCC,CSIC USAL,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Gen Serv Cytometry, Campus Miguel Unamuno S-N, Salamanca 37007, Spain.;Univ Salamanca, CSIC, Prote Unit, Canc Res Ctr IBMCC,IBSAL, Campus Miguel Unamuno S-N, Salamanca 37007, Spain. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancers: MDPI AG14:22072-6694

Internetlänk

Hitta via bibliotek

  • Cancers (Sök värdpublikationen i LIBRIS)

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