Protein profiles in plasma : Development from infancy to 5 years of age

• Purpose: Little is known about the longitudinal development of different plasma protein levels during early childhood and particularly in relation to lifestyle factors. This study aimed to monitor the plasma proteome early in life and the influence of different lifestyles. Experimental Design: A multiplex bead-based immunoassay was used to analyze plasma levels of 97 proteins in 280 blood samples longitudinally collected in children at 6, 12, 24, and 60 months of age living in families with an anthroposophic (n = 15), partly anthroposophic (n = 27), or non-anthroposophic (n = 28) lifestyle. Results: A total of 68 proteins (70%) showed significantly altered plasma levels between 6 months and 5 years of age. In lifestyle stratified analysis, 59 of 97 (61%) proteins were altered over time within one or more of the three lifestyle groups. Nearly half of these proteins (28 out of 59) changed irrespective of lifestyle. The temporal changes represented four longitudinal trends of the plasma proteins during development, also following stratification of lifestyle. Conclusions and Clinical Relevance: Our findings contribute to understand the development of the plasma proteome under the influence of lifestyle exposures in early childhood.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

ALADDIN

childhood

lifestyle

longitudinal

antibiotic agent

apolipoprotein A1

CD40 antigen

interleukin 13

plasma protein

tumor necrosis factor

vaccine

proteome

anthroposophic medicine

Article

artificial milk

blood sampling

breast feeding

cesarean section

child

controlled study

correlation analysis

drug use

family life

female

home delivery

human

immunoassay

infant

male

maternal nutrition

normal human

preschool child

protein analysis

proteomics

quality control

statistical analysis

vaccination

vegetarian diet

alternative medicine

longitudinal study

Sweden

Anthroposophy

Blood Proteins

Child

Preschool

Humans

Life Style

Longitudinal Studies

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)