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Fully automatic est...
Fully automatic estimation of the waist of the nerve fiber layer at the optic nerve head angularly resolved
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- Brusini, Irene (författare)
- KTH,Medicinsk avbildning,Karolinska Institute (Sweden),Medicinsk avbildning, Inst. f. Medicinteknik och hälsosystem, KTH
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- Carrizo, Garrizo (författare)
- KTH,Medicinsk avbildning,KTH, Dept. of Biomedical Engineering and Health Systems,Chunliang Wang
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- Bendazzoli, Simone (författare)
- KTH,Medicinteknik och hälsosystem,KTH, Dept. of Biomedical Engineering and Health Systems
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- Wang, Chunliang, 1980- (författare)
- KTH,Medicinsk avbildning,KTH, Dept. of Biomedical Engineering and Health Systems
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- Yu, Zhaohua, 1983- (författare)
- Uppsala universitet,Oftalmiatrik,University hospital, Uppsala, Sweden,Per Söderberg
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- Sandberg Melin, Camilla (författare)
- Uppsala universitet,Oftalmiatrik,Centrum för klinisk forskning, Gävleborg,Per Söderberg
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- Kisonaite, Konstancija (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Per Söderberg
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- Raeme, Faisal (författare)
- Uppsala universitet,Institutionen för neurovetenskap,Per Söderberg
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- Söderberg, Per, 1956- (författare)
- Uppsala universitet,Oftalmiatrik,Per Söderberg
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(creator_code:org_t)
- SPIE-Intl Soc Optical Eng, 2021
- 2021
- Engelska.
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Ingår i: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. - : SPIE-Intl Soc Optical Eng. ; , s. 1D1-1D8
- Relaterad länk:
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https://www.spiedigi...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The present project aims at developing a fully automatic software for estimation of the waist of the nerve fiber layer in the Optic Nerve Head (ONH) angularly resolved in the frontal plane as a tool for morphometric monitoring of glaucoma. The waist of the nerve fiber layer is here defined as Pigment epithelium central limit –Inner limit of the retina – Minimal Distance, (PIMD). 3D representations of the ONH were collected with high resolution OCT in young not glaucomatous eyes and glaucomatous eyes. An improved tool for manual annotation was developed in Python. This tool was found user friendly and to provide sufficiently precise manual annotation. PIMD was automatically estimated with a software consisting of one AI model for detection of the inner limit of the retina and another AI model for localization of the Optic nerve head Pigment epithelium Central limit (OPCL). In the current project, the AI model for OPCL localization was retrained with new data manually annotated with the improved tool for manual annotation both in not glaucomatous eyes and in glaucomatous eyes. Finally, automatic annotations were compared to 3 annotations made by 3 independent annotators in an independent subset of both the not glaucomatous and the glaucomatous eyes. It was found that the fully automatic estimation of PIMD-angle overlapped the 3 manual annotators with small variation among the manual annotators. Considering interobserver variation, the improved tool for manual annotation provided less variation than our original annotation tool in not glaucomatous eyes suggesting that variation in glaucomatous eyes is due to variable pathological anatomy, difficult to annotate without error. The small relative variation in relation to the substantial overall loss of PIMD in the glaucomatous eyes compared to the not glaucomatous eyes suggests that our software for fully automatic estimation of PIMD-angle can now be implemented clinically for monitoring of glaucoma progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Artificial intelligence (AI)
- Glaucoma
- Morphometry
- Nerve fiber layer waist
- ONH
- PIMD
- Ophthalmology
- 3d representations
- Automatic annotation
- Automatic estimation
- Current projects
- Interobserver variations
- Manual annotation
- Minimal distance
- Nerve fiber layers
- Eye protection
- Ophtalmology
Publikations- och innehållstyp
- ref (ämneskategori)
- kon (ämneskategori)
- Av författaren/redakt...
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Brusini, Irene
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Carrizo, Garrizo
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Bendazzoli, Simo ...
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Wang, Chunliang, ...
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Yu, Zhaohua, 198 ...
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Sandberg Melin, ...
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visa fler...
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Kisonaite, Konst ...
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Raeme, Faisal
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Söderberg, Per, ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
- Artiklar i publikationen
- Progress in Biom ...
- Av lärosätet
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Kungliga Tekniska Högskolan
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Uppsala universitet