Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19

• COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) consisting of glutathione and NAD+ precursors can restore metabolic function and thus aid the recovery of COVID-19 patients. CMAs include l-serine, N-acetyl-l-cysteine, nicotinamide riboside, and l-carnitine tartrate, salt form of l-carnitine. Placebo-controlled, open-label phase 2 study and double-blinded phase 3 clinical trials are conducted to investigate the time of symptom-free recovery on ambulatory patients using CMAs. The results of both studies show that the time to complete recovery is significantly shorter in the CMA group (6.6 vs 9.3 d) in phase 2 and (5.7 vs 9.2 d) in phase 3 trials compared to placebo group. A comprehensive analysis of the plasma metabolome and proteome reveals major metabolic changes. Plasma levels of proteins and metabolites associated with inflammation and antioxidant metabolism are significantly improved in patients treated with CMAs as compared to placebo. The results show that treating patients infected with COVID-19 with CMAs lead to a more rapid symptom-free recovery, suggesting a role for such a therapeutic regime in the treatment of infections leading to respiratory problems.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

combined metabolic activators

COVID-19

metabolomics

omics data

proteomics

Acetylcysteine

Amino acids

Metabolism

Metabolites

Patient monitoring

Patient treatment

Peptides

Recovery

Ambulatory patients

Comprehensive analysis

Glutathione metabolism

Metabolic function

Mitochondrial dysfunction

N-acetyl l-cysteine

Nicotinamide adenine dinucleotides

Respiratory problems

Patient rehabilitation

antioxidant

protein

proteome

adult

aged

blood

clinical trial

controlled study

double blind procedure

female

human

inflammation

male

metabolome

middle aged

phase 2 clinical trial

phase 3 clinical trial

physiology

randomized controlled trial

young adult

Antioxidants

Double-Blind Method

Humans

Proteins

combined metabolic activators

COVID-19

metabolomics

omics data

proteomics

Acetylcysteine

Amino acids

Metabolism

Metabolites

Patient monitoring

Patient treatment

Peptides

Recovery

Ambulatory patients

Comprehensive analysis

Glutathione metabolism

Metabolic function

Mitochondrial dysfunction

N-acetyl l-cysteine

Nicotinamide adenine dinucleotides

Respiratory problems

Patient rehabilitation

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